In vitro evaluation of kaempferol-loaded hydrogel as pH-sensitive drug delivery systems

Q Zhang, X Yang, Y Wu, C Liu, H Xia, X Cheng… - Polymers, 2022 - mdpi.com
The purpose of this study was to prepare and evaluate kaempferol-loaded carbopol polymer
(acrylic acid) hydrogel, investigate its antioxidant activity in vitro, and compare the effects on …

Natural marine and terrestrial compounds as modulators of matrix metalloproteinases-2 (MMP-2) and MMP-9 in Alzheimer's disease

L Ciccone, J Vandooren, S Nencetti, E Orlandini - Pharmaceuticals, 2021 - mdpi.com
Several studies have reported neuroprotective effects by natural products. A wide range of
natural compounds have been investigated, and some of these may play a beneficial role in …

Network pharmacology- and molecular docking-based analyses of the antihypertensive mechanism of Ilex kudingcha

F Liao, M Yousif, R Huang, Y Qiao, Y Hu - Frontiers in Endocrinology, 2023 - frontiersin.org
Herein, network pharmacology was used to identify the active components in Ilex kudingcha
and common hypertension-related targets. Gene Ontology (GO) and Kyoto Encyclopedia of …

The effect of polyphenols on kidney disease: Targeting mitochondria

F Ashkar, KS Bhullar, J Wu - Nutrients, 2022 - mdpi.com
Mitochondrial function, including oxidative phosphorylation (OXPHOS), mitochondrial
biogenesis, and mitochondria dynamics, are essential for the maintenance of renal health …

Kaempferol modulates IFN-γ induced JAK-STAT signaling pathway and ameliorates imiquimod-induced psoriasis-like skin lesions

Y Li, H Cui, S Li, X Li, H Guo, KS Nandakumar… - International …, 2023 - Elsevier
Immune-mediated inflammation contributes to the development of psoriasis. However, long-
term treatment with global immunosuppressive agents may cause a variety of side effects …

Effect of kaempferol and its glycoside derivatives on antioxidant status of HL-60 cells treated with etoposide

M Kluska, M Juszczak, J Żuchowski, A Stochmal… - Molecules, 2022 - mdpi.com
Kaempferol is a well-known antioxidant found in many plants and plant-based foods. In
plants, kaempferol is present mainly in the form of glycoside derivatives. In this work, we …

A Critical Review of Kaempferol in Intestinal Health and Diseases

J Chen, H Zhong, Z Huang, X Chen, J You, T Zou - Antioxidants, 2023 - mdpi.com
Kaempferol, a secondary metabolite found in plants, is a naturally occurring flavonoid
displaying significant potential in various biological activities. The chemical structure of …

Psidium guajava L.: A Systematic Review of the Multifaceted Health Benefits and Economic Importance

LN Takeda, LF Laurindo, EL Guiguer… - Food Reviews …, 2023 - Taylor & Francis
The lifestyle changes observed in recent years are related to the increase in the chronic
diseases that have become the main causes of mortality and increased expenditure on …

The therapeutic potential of Kaemferol and other naturally occurring polyphenols might Be modulated by Nrf2-ARE Signaling pathway: current status and future …

Y Hussain, H Khan, KF Alsharif, A Hayat Khan… - Molecules, 2022 - mdpi.com
Kaempferol is a natural flavonoid, which has been widely investigated in the treatment of
cancer, cardiovascular diseases, metabolic complications, and neurological disorders. Nrf2 …

Kaempferol prevents cadmium chloride-induced liver damage by upregulating Nrf2 and suppressing NF-κB and keap1

AS Alshehri, AF El-Kott, MSA El-Gerbed… - … Science and Pollution …, 2022 - Springer
This study evaluated the protective effect of kaempferol, a natural flavonoid, against
cadmium chloride (CdCl 2)-induced liver damage and examined the possible anti …