PTEN is a tumor suppressor gene mutated in various advanced human neoplasias,
including glioblastomas and prostate, breast, endometrial, and kidney cancers. This tumor …

High levels of DNA and RNA released by apoptotic and necrotic cells circulate in the blood
of cancer patients. In the present study we determined the applicability of the quantification …

In 1997, PTEN (phosphatase and tensin homologue deleted on chromosome 10, 10q23. 3)
was identified as an important tumor suppressor gene that is inactivated in a wide variety of …

Epithelial apoptosis has a key role in the development and function of the mammary gland. It
is involved with the formation of ducts during puberty and is required to remove excess …

Phosphoinositide phosphatases comprise several large enzyme families with over 35
mammalian enzymes identified to date that degrade many phosphoinositide signals. Growth …

The protein serine/threonine kinase Akt, also known as protein kinase B (PKB), is arguably
the most important signalling nexus in the cell. Akt integrates a plethora of extracellular …

Oncogenic lesions are surprisingly common in morphologically and functionally normal
human skin. However, the cellular and molecular mechanisms that suppress their cancer …

Germline pathogenic phosphatase and tensin homolog (PTEN) mutations cause PTEN
hamartoma tumor syndrome (PHTS), characterized by various benign and malignant tumors …

BACKGROUND & AIMS: Some clinical findings have suggested that systemic metabolic
disorders accelerate in vivo tumor progression. Deregulation of the phosphatidylinositol 3 …

The molecular mechanism for the beneficial effect of fish oil on breast tumor growth is largely
undefined. Using the xenograft model in nude mice, we for the first time report that the fish oil …