To study the role of the Pten tumor suppressor in skeletogenesis, we generated mice lacking
this key phosphatidylinositol 3′‐kinase pathway regulator in their osteo …

Breast cancer is a highly complicated disease. Advancement in the treatment and
prevention of breast cancer lies in elucidation of the mechanism of carcinogenesis and …

Ultraviolet (UV) radiation in sunlight is the major environmental cause of skin cancer. PTEN
(phosphatase and tensin homolog deleted on chromosome 10) is a proven critical tumor …

Stat5 (signal transducer and activator of transcription 5) is an essential mediator of cytokine
receptor signaling and plays important roles in the proliferation of alveolar progenitors and …

Oncogenic mutations in PIK3CA, which encodes the phosphoinositide-3-kinase (PI3K)
catalytic subunit p110α, occur in∼ 25% of human breast cancers. In this study, we report the …

Recent progress in understanding the molecular mechanisms of receptor signal
transduction is continuously highlighting new unforeseen potential drug targets for yet unmet …

Neutrophil spontaneous death plays essential roles in neutrophil homeostasis and
resolution of inflammation, whereas the underlying molecular mechanisms are still ill …

Akt phosphorylation is a major driver of cell survival, motility, and proliferation in
development and disease, causing increased interest in upstream regulators of Akt like …

Abstract Everolimus (RAD001, Afinitor®) is an oral, selective mTOR inhibitor recently
approved by the US-FDA in combination with exemestane for treatment of hormone receptor …

The three Akt isoforms differ in their ability to transduce oncogenic signals initiated by the
Neu and PyMT oncogenes in mammary epithelia. As a result, ablation of Akt1 inhibits and …