Molecularly targeted cancer therapies substantially improve patient outcomes, although the
durability of their effectiveness can be limited. Resistance to these therapies is often related …

Introduction: Adverse immune activation contributes to many central nervous system (CNS)
disorders. All main CNS cell types express toll-like receptor 4 (TLR 4). This receptor is …

Background Alzheimer's disease is the most prevalent cause of dementia in the elderly.
Neuronal death and synaptic dysfunctions are considered the main hallmarks of this …

Cognitive impairment in Alzheimer's disease (AD) is associated with dysregulation of the
RNA and protein expression profiles in the brain. Recent studies have highlighted the …

Given the importance of ubiquitin-specific protease 7 (USP7) in oncogenic pathways,
identification of USP7 inhibitors has attracted considerable interest. Despite substantial …

The protein dyshomeostasis is identified as the hallmark of many age-related
neurodegenerative disorders including Parkinson's disease (PD). The diseased brain shows …

Neurodegenerative diseases, characterized by a progressive loss of brain function, affect
the lives of millions of individuals worldwide. The complexity of the brain poses a challenge …

Retinal remodeling is a progressive series of negative plasticity revisions that arise from
retinal degeneration, and are seen in retinitis pigmentosa, age-related macular …

One of the hallmark features in the neurodegenerative disorders (NDDs) is the accumulation
of aggregated and/or non-functional protein in the cellular milieu. Post-translational …

The ubiquitin-proteasome pathway (UPP) is involved in regulating several biological
functions, including cell cycle control, apoptosis, DNA damage response, and apoptosis. It is …