Although anxiety and depression have been considered as two distinct entities according to
the diagnostic criteria, anxious depression (comorbid anxiety and depression) is relatively a …

Depression remains a debilitating condition with an uncertain aetiology. Recently, attention
has been given to the renin–angiotensin system. In the central nervous system, angiotensin …

Background. To examine cross-national patterns and correlates of lifetime and 12-month
comorbid DSM-IV anxiety disorders among people with lifetime and 12-month DSM-IV major …

Objective: To evaluate the efficacy and safety of zuranolone, an investigational neuroactive
steroid and GABA A receptor positive allosteric modulator, in major depressive disorder …

Mood and psychotic syndromes most often emerge during adolescence and young
adulthood, a period characterised by major physical and social change. Consequently, the …

Abstract Treatment-resistant depression (TRD) is a major contributor to the disability caused
by major depressive disorder (MDD). Primary care electronic health records provide an …

BackgroundMajor depressive disorder (MDD) is a highly heterogeneous condition in terms
of symptom presentation and, likely, underlying pathophysiology. Accordingly, it is possible …

Importance Major depressive disorder (MDD) remains challenging to treat. Although several
clinical and demographic variables have been found to predict poor antidepressant …

Major depression is prevalent after traumatic brain injury (TBI) and associated with poor
outcomes. Little is known about the course of depression after TBI. Participants were 559 …

Background Treatment for depressive disorders often requires subsequent interventions.
Patients who do not respond to antidepressants have treatment‐resistant depression (TRD) …