Azoospermia affects 1% of men, and it can be due to:(i) hypothalamic-pituitary
dysfunction,(ii) primary quantitative spermatogenic disturbances,(iii) urogenital duct …

Background and objectives: XX male syndrome is part of the disorders of sex development
(DSD). The patients generally have normal external genitalia and discover their pathology in …

Background Disorders of sex development (DSD) are congenital conditions in which
chromosomal, gonadal, or phenotypic sex is atypical. Clinical management of DSD is often …

Female-to-male sex reversals (pseudomales) are common in lower vertebrates and have
been found in natural populations, which is a concern under rapid changes in environmental …

Squamous cell carcinoma antigen recognized by T cells 3 (SART3) is an RNA-binding
protein with numerous biological functions including recycling small nuclear RNAs to the …

Background To review the possible mechanisms proposed to explain the etiology of 46, XX
sex reversal by investigating the clinical characteristics and their relationships with …

Androgens and anti-Müllerian hormone (AMH), secreted by the foetal testis, are responsible
for the development of male reproductive organs and the regression of female anlagen …

Disorders of Sex Development (DSD) are congenital anomalies in which there is a
discordance between chromosomal, genetic, gonadal, and/or internal/external genital sex …

One of the defining events during human embryonic development with the most far-reaching
effects for the individual is whether the embryo develops as male or female. The crucial step …

Despite considerable research effort and significant advances in sequencing technologies,
the majority of disorders of sex development (DSD) cases still lack a molecular genetic …