Targeting circular RNAs as a therapeutic approach: current strategies and challenges
Significant progress has been made in circular RNA (circRNA) research in recent years.
Increasing evidence suggests that circRNAs play important roles in many cellular processes …
Increasing evidence suggests that circRNAs play important roles in many cellular processes …
Emerging targets in type 2 diabetes and diabetic complications
S Demir, PP Nawroth, S Herzig… - Advanced …, 2021 - Wiley Online Library
Type 2 diabetes is a metabolic, chronic disorder characterized by insulin resistance and
elevated blood glucose levels. Although a large drug portfolio exists to keep the blood …
elevated blood glucose levels. Although a large drug portfolio exists to keep the blood …
[HTML][HTML] HO-1-mediated ferroptosis as a target for protection against retinal pigment epithelium degeneration
Z Tang, Y Ju, X Dai, N Ni, Y Liu, D Zhang, H Gao… - Redox biology, 2021 - Elsevier
Oxidative stress-mediated retinal pigment epithelium (RPE) degeneration plays a vital role
in retinal degeneration with irreversible visual impairment, most notably in age-related …
in retinal degeneration with irreversible visual impairment, most notably in age-related …
Pericytes in the disease spotlight
H van Splunder, P Villacampa, A Martínez-Romero… - Trends in Cell …, 2024 - cell.com
Pericytes are known as the mural cells in small-caliber vessels that interact closely with the
endothelium. Pericytes play a key role in vasculature formation and homeostasis, and when …
endothelium. Pericytes play a key role in vasculature formation and homeostasis, and when …
[HTML][HTML] Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments
Nowadays, diabetes mellitus has emerged as a significant global public health concern with
a remarkable increase in its prevalence. This review article focuses on the definition of …
a remarkable increase in its prevalence. This review article focuses on the definition of …
Circular RNAs in kidney disease and cancer
Circular RNAs (circRNAs) are a class of endogenously expressed regulatory RNAs with a
single-stranded circular structure. They are generated by back splicing and their expression …
single-stranded circular structure. They are generated by back splicing and their expression …
Baicalein limits osteoarthritis development by inhibiting chondrocyte ferroptosis
Y Wan, H Yu, W Fan - Free Radical Biology and Medicine, 2023 - Elsevier
Osteoarthritis (OA) is a common degenerative disease of articular cartilage, and there is
currently no effective treatment. Baicalein, a flavonoid extracted from plants of the Scutellaria …
currently no effective treatment. Baicalein, a flavonoid extracted from plants of the Scutellaria …
Circular RNA: an important player with multiple facets to regulate its parental gene expression
T Shao, Y Pan, X Xiong - Molecular Therapy-Nucleic Acids, 2021 - cell.com
Circular RNAs (circRNAs), a novel type of endogenous RNAs with covalently closed-loop
structures, have become a new research hotspot in the RNA world. Their diversity, stability …
structures, have become a new research hotspot in the RNA world. Their diversity, stability …
[HTML][HTML] Different types of cell death in diabetic endothelial dysfunction
J Shen, W San, Y Zheng, S Zhang, D Cao… - Biomedicine & …, 2023 - Elsevier
Diabetes mellitus is a metabolic disease caused by disorders of insulin secretion and
utilization. Long-term hyperglycemia, insulin resistance, and disorders of glucose and lipid …
utilization. Long-term hyperglycemia, insulin resistance, and disorders of glucose and lipid …
[HTML][HTML] METTL3-mediated N6-methyladenosine modification governs pericyte dysfunction during diabetes-induced retinal vascular complication
L Suo, C Liu, QY Zhang, MD Yao, Y Ma, J Yao… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: Microvascular complication is a major cause of morbidity and mortality among the
patients with diabetes. Pericyte dysfunction is the predominant pathological manifestation of …
patients with diabetes. Pericyte dysfunction is the predominant pathological manifestation of …