Having a hypoxic microenvironment is a common and salient feature of most solid tumors.
Hypoxia has a profound effect on the biological behavior and malignant phenotype of …

Given that hypoxia is a persistent physiological feature of many different solid tumors and a
key driver for cancer malignancy, it is thought to be a major target in cancer treatment …

Tumor hypoxia resulting from abnormal and dysfunctional tumor vascular network poses a
substantial obstacle to immunotherapy. In fact, hypoxia creates an immunosuppressive …

Background Tumor-associated macrophages (TAMs) are a major component of the tumor
microenvironment (TME) and exert an important role in tumor progression. Due to the …

Macrophages are ancient, phagocytic immune cells thought to have their origins 500 million
years ago in metazoan phylogeny. The understanding of macrophages has evolved to …

Background Gastric cancer (GC) is a malignant tumour, with high morbidity and mortality
rates worldwide. The occurrence and development of GC is a complex process involving …

Lupus nephritis (LN) is a serious complication of systemic lupus erythematosus (SLE) and a
leading cause of mortality. Luteolin (LUT), a compound found in many vegetables, fruits, and …

The diverse bacterial populations within the symbiotic microbiota play a pivotal role in both
health and disease. Microbiota modulates critical aspects of tumor biology including cell …

Oral squamous cell carcinoma (OSCC) is the most prevalent form of oral and maxillofacial
malignancies, characterized by a low five-year survival rate primarily caused by invasion …

The gastric mucosal immune system is a unique immune organ independent of systemic
immunity that not only maintains nutrient absorption but also plays a role in resisting the …