Background and purpose Minocycline is a broad‐spectrum antibiotic, effective as a chronic
treatment for recurrent bacterial infections. Beyond its antibiotic action, minocycline also has …

Stress has been well documented to bring about various clinical disorders, ranging from
neurodegeneration, such as Parkinson's (PD) and Alzheimer's diseases (AD), to metabolic …

Background Anxiety disorders are the most prevalent mental illnesses in the US and are
estimated to consume one-third of the country's mental health treatment cost. Although …

High trait anxiety is a substantial risk factor for developing anxiety disorders and depression.
While neuroinflammation has been identified to contribute to stress-induced anxiety, little is …

The dysregulation of tryptophan-kynurenine pathway (TKP) is extensively involved in the
pathophysiology of Alzheimer's disease, depression, and neurodegenerative disorders …

Depression and anxiety have been reported as the major neuropsychiatric consequences
following stroke. Minocycline, a neuroprotective drug has minimized depressive symptoms …

Antibiotics exposure leads to gut microbiota dysbiosis, which increases the risk of anxiety
and depression. However, the impact of ciprofloxacin and metronidazole exposure on …

Stress and substance use disorders remain two of the most highly prevalent psychiatric
conditions and are often comorbid. While individually these conditions have a debilitating …

Background Women are at increased risk for psychosocial stress-related anxiety disorders,
yet mechanisms regulating this risk are unknown. Psychosocial stressors activate microglia …

Stress is an important factor in the development of several human pathologies. The
response of rodents and humans to stress depends on many factors; some people and …