Adenosine deaminase acting on RNA (ADAR) catalyzes the posttranscriptional conversion
of adenosine to inosine in double‐stranded RNA (dsRNA), which can lead to the creation of …

In addition to susceptibility to infections, conventional primary immunodeficiency disorders
(PIDs) and inborn errors of immunity (IEI) can cause immune dysregulation, manifesting as …

Objective Autoinflammatory type I interferonopathies, chronic atypical neutrophilic
dermatosis with lipodystrophy and elevated temperature/proteasome‐associated …

Background Elevated production of the cytokines interleukin (IL)-6 or interferon (IFN)-α in the
central nervous system (CNS) is implicated in the pathogenesis of neurological diseases …

Innate immune sensors that detect nucleic acids are attractive targets for therapeutic
intervention because of their diverse roles in many disease processes. In detecting RNA and …

With aging, the incidence of age-related diseases increases. Hence, age-related diseases
are inevitable. However, the mechanisms by which aging leads to the onset and progression …

Detection of microbial nucleic acids by the innate immune system is mediated by numerous
intracellular nucleic acids sensors. Upon the detection of nucleic acids these sensors induce …

Cellular stress in the form of disrupted transcription, loss of organelle integrity, or damage to
nucleic acids can elicit inflammatory responses by activating signaling cascades canonically …

Abstract Background Aicardi-Goutières syndrome (AGS) is a severe infant or juvenile-onset
autoimmune disease characterized by inflammatory encephalopathy with an elevated type 1 …

Objectives To test the hypothesis that ROSAH (retinal dystrophy, optic nerve oedema,
splenomegaly, anhidrosis and headache) syndrome, caused by dominant mutation in …