Peroxisomes are unique among the organelles of the endomembrane system. Unlike other
organelles that derive most if not all of their proteins from the ER (endoplasmic reticulum) …

ATP-binding cassette (ABC) transporters belong to one of the largest families of membrane
proteins, and are present in almost all living organisms from eubacteria to mammals. They …

Structural resolution of protein interactions enables mechanistic and functional studies as
well as interpretation of disease variants. However, structural data is still missing for most …

Melanomas reprogram their metabolism to rapidly adapt to therapy-induced stress
conditions, allowing them to persist and ultimately develop resistance. We report that a …

Mitochondria and peroxisomes are independent but functionally closely related organelles.
A few proteins have been characterized as dual-organelle locating proteins with distinct or …

Proper localization of membrane proteins is essential for the function of biological
membranes and for the establishment of organelle identity within a cell. Molecular …

Peroxisomes are conserved organelles of eukaryotic cells with important roles in cellular
metabolism, human health, redox homeostasis, as well as intracellular metabolite transfer …

Eukaryotic cells compartmentalize biochemical reactions into membrane‐enclosed
organelles that must be faithfully propagated from one cell generation to the next. Transport …

Lipid droplets (LDs) are endoplasmic reticulum (ER)-derived lipid storage organelles
uniquely encapsulated by phospholipid monolayers. LD membrane proteins are embedded …

The advent of complex multicellularity (CM) was a pivotal event in the evolution of animals,
plants and fungi. In the fungal Ascomycota, CM is based on hyphal filaments and arose in …