Exercise performance is determined by oxygen supply to working muscles and vital organs.
In healthy individuals, exercise performance is limited in the hypoxic environment at altitude …

Older individuals represent a growing population, in industrialized countries, particularly
those with cardiovascular diseases, which remain the leading cause of death in western …

BACKGROUND. Iron bioavailability has been identified as a factor that influences cellular
hypoxia sensing, putatively via an action on the hypoxia-inducible factor (HIF) pathway. We …

This pre-eminent work has developed over six editions in response to man's attempts to
climb higher and higher unaided, and to spend more time at altitude for both work and …

Background There is insufficient evidence to counsel patients with pulmonary hypertension
undergoing altitude or air travel. We thus aimed to study hemodynamic response of patients …

The current pandemic of surgical complications necessitates urgent and pragmatic
innovation to reduce postoperative morbidity and mortality, which are associated with poor …

New Findings What is the central question of this study? Pulmonary arterial pressure is
higher in older than younger humans and predicts mortality. It is also increased by acute …

In older individuals, pulmonary artery pressure rises markedly during exercise, probably due
in part to increased pulmonary vascular resistance and in part to an increase in left‐heart …

Human exposure to hyperbaric pressure occurs while diving and during hyperbaric oxygen
therapy. Hypobaric exposures occur on commercial plane flights where the cabin pressure …

BACKGROUND: Members of the public will soon be taking commercial suborbital
spaceflights with significant Gx (chest-to-back) acceleration potentially reaching up to 6 Gx …