Nonlinear mixed effects models for data in the form of continuous, repeated measurements
on each of a number of individuals, also known as hierarchical nonlinear models, are a …

The prevalence of obesity in the western world is dramatically rising, with many of these
individuals requiring therapeutic intervention for a variety of disease states. Despite the …

Population pharmacokinetic models are used to describe the time course of drug exposure
in patients and to investigate sources of variability in patient exposure. They can be used to …

Background Unresolved issues with propofol include whether the pharmacokinetics are
linear with dose, are influenced by method of administration (bolus vs. infusion), or are …

Background Previous studies have reported conflicting results concerning the influence of
age and gender on the pharmacokinetics and pharmacodynamics of fentanyl, alfentanil, and …

Nonlinear measurement data arise in a wide variety of biological and biomedical
applications, such as longitudinal clinical trials, studies of drug kinetics and growth, and the …

PsN-Toolkit is a collection of statistical tools for pharmacometric data analysis using the non-
linear mixed effect modeling software NONMEM. The toolkit is object oriented and written in …

The building of population pharmacokinetic/pharmacodynamic (PK/PD) models is a time
consuming and complicated task. This is partly due the lack of specialized tools for the …

The focus of this book is primarily on the development of pharmacokinetic and
pharmacokinetic-pharmacodynamic models. Models that are reported in the literature are …

Background Infliximab (IFX) is effective therapy for ulcerative colitis and Crohn's disease, but
it may be associated with side effects and loss of response. One loss of response …