Nitrofurantoin (NF), a wide-spectrum antibiotic accessible since 1953, is utilized widely to
treat urinary tract infections as it usually stays active against drug-resistant uropathogen. The …

Antimicrobial peptides (AMPs) have shown cell membrane-directed mechanisms of action.
This specificity can be effective against infectious agents that have acquired resistance to …

Introduction A considerable number of morbidities and fatalities occur worldwide as a result
of the multidrug resistant microorganisms that cause a high prevalence of nosocomial …

Multidrug resistance (MDR) pathogens are usually associated with higher morbidity and
mortality rates. Flavonoids are good candidates for the development of new potential …

Phosphonic acids represent a class of important structural units widely found in natural
products and artificially synthesized functional molecules. Nature uses β-carbonyl …

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most dreadful pathogens
relevant in community and nosocomial-related infections around the world. Resensitising …

Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are a global health
concern. The propensity of MRSA to form biofilms is a significant contributor to its …

The identification of genes associated with resistance has the potential to facilitate the
development of novel diagnostic tests and treatment methods. The objective of this study …

The golden age of antibiotic discovery was marked not only by the discovery of numerous
new antibiotic structures but also by the recurring correlation of these antibiotics to two …

细菌耐药性的持续攀升及新型抗菌药物研发进展缓慢, 使得临床抗感染治疗面临巨大挑战.
早期抗生素呋喃妥因具有较强的抗菌活性和较低的临床耐药率, 被重新考虑作为治疗尿路感染的 …