Immuno-modulatory effects of intervertebral disc cells
P Bermudez-Lekerika, KB Crump… - Frontiers in cell and …, 2022 - frontiersin.org
Low back pain is a highly prevalent, chronic, and costly medical condition predominantly
triggered by intervertebral disc degeneration (IDD). IDD is often caused by structural and …
triggered by intervertebral disc degeneration (IDD). IDD is often caused by structural and …
Cartilaginous endplates: A comprehensive review on a neglected structure in intervertebral disc research
KB Crump, A Alminnawi, P Bermudez‐Lekerika… - JOR …, 2023 - Wiley Online Library
The cartilaginous endplates (CEP) are key components of the intervertebral disc (IVD)
necessary for sustaining the nutrition of the disc while distributing mechanical loads and …
necessary for sustaining the nutrition of the disc while distributing mechanical loads and …
[HTML][HTML] High resolution 16S rRNA gene Next Generation Sequencing study of brain areas associated with Alzheimer's and Parkinson's disease
DC Emery, M Davies, TL Cerajewska… - Frontiers in Aging …, 2022 - frontiersin.org
Alzheimer's (AD) and Parkinson's disease (PD) are neurodegenerative conditions
characterised by incremental deposition of proteinaceous pathologies in relatively …
characterised by incremental deposition of proteinaceous pathologies in relatively …
Would Cutibacterium acnes Be the Villain for the Chronicity of Low Back Pain in Degenerative Disc Disease? Preliminary Results of an Analytical Cohort
VM da Rocha, COGX Lima, GB Candido… - Journal of personalized …, 2023 - mdpi.com
In the last decade, several studies have demonstrated Cutibacterium acnes colonization in
intervertebral discs (IVDs) in patients with lumbar disc degeneration (LDD) and low back …
intervertebral discs (IVDs) in patients with lumbar disc degeneration (LDD) and low back …
[HTML][HTML] Low back pain patients with Modic type 1 changes exhibit distinct bacterial and non-bacterial subtypes
Objectives Modic type 1 changes (MC1) are vertebral endplate bone marrow (BM) lesions
observed on magnetic resonance images in sub-populations of chronic low back pain …
observed on magnetic resonance images in sub-populations of chronic low back pain …
[HTML][HTML] Propionibacterium acnes contributes to low back pain via upregulation of NGF in TLR2-NF-κB/JNK or ROS pathway
Y Jiao, Y Lin, J Zheng, L Shi, Y Zheng, Y Zhang, J Li… - Microbes and …, 2022 - Elsevier
Propionibacterium acnes infection in intervertebral discs (IVDs) is a newly identified cause of
low back pain (LBP). In the present study, we aimed to determine whether the nerve growth …
low back pain (LBP). In the present study, we aimed to determine whether the nerve growth …
Evaluation of Antibacterial Drugs Using Silkworms Infected by Cutibacterium acnes
Y Matsumoto, Y Tateyama, T Sugita - Insects, 2021 - mdpi.com
Simple Summary Cutibacterium acnes, a common bacterium on human skin, is a causative
agent of inflammatory skin diseases and systemic infections. Systemic infections caused by …
agent of inflammatory skin diseases and systemic infections. Systemic infections caused by …
Intervertebral disc cell chondroptosis elicits neutrophil response in Staphylococcus aureus spondylodiscitis
TA Schweizer, F Andreoni, C Acevedo… - Frontiers in …, 2022 - frontiersin.org
To understand the pathophysiology of spondylodiscitis due to Staphylococcus aureus, an
emerging infectious disease of the intervertebral disc (IVD) and vertebral body with a high …
emerging infectious disease of the intervertebral disc (IVD) and vertebral body with a high …
The role of the complement system in disc degeneration and Modic changes
Disc degeneration and vertebral endplate bone marrow lesions called Modic changes are
prevalent spinal pathologies found in chronic low back pain patients. Their …
prevalent spinal pathologies found in chronic low back pain patients. Their …
Intervertebral disc microbiome in Modic changes: Lack of result replication underscores the need for a consensus in low‐biomass microbiome analysis
Introduction The emerging field of the disc microbiome challenges traditional views of disc
sterility, which opens new avenues for novel clinical insights. However, the lack of …
sterility, which opens new avenues for novel clinical insights. However, the lack of …