Exaggeration of type 2 immune responses promotes lung inflammation and altered lung
development; however, eosinophils, despite expansion in the postnatal lung, have not been …

Eosinophils are key effector cells mediating airway inflammation and exacerbation in
patients with severe eosinophilic asthma. They are present in increased numbers and …

Asthma affects 25 million Americans, and recent advances in treatment are effective for only
a portion of severe asthma patients. TREM-1, an innate receptor that canonically amplifies …

Ulcerative colitis (UC) is a chronic disorder of the large intestine with inflammation and
ulceration. The incidence and prevalence of UC have been rapidly increasing worldwide …

Eosinophils function as inflammatory effectors in allergic diseases but also contribute to
tissue homeostasis in steady state. Emerging data are revealing tissue eosinophils to be …

In a recent study published in Nature, Gurtner and colleagues identify active eosinophils (A-
Eos) as eosinophil subset with antibacterial and immune regulatory functions during …

Eosinophils have been mainly studied in allergic diseases and parasitic infections.
Nonetheless, eosinophils accumulate in a variety of solid tumors, including colorectal …

Traditionally, eosinophils have been linked to parasitic infections and pathological disease
states. However, emerging literature has unveiled a more nuanced and intricate role for …

Intestinal eosinophils express the aryl hydrocarbon receptor (AHR), an environmental
sensor and ligand-activated transcription factor that responds to dietary or environmental …

Abstract Introduction: Interleukin-4 (IL-4) is a central regulator of type 2 immunity, crucial for
the defense against multicellular parasites like helminths. This study focuses on its roles and …