Intestinal helminth infection triggers a type 2 immune response that promotes a 'weep-and
sweep'response characterised by increased mucus secretion and intestinal hypermotility …

Single-cell RNA sequencing of human blood eosinophils reveals plasticity and absence of
canonical cell subsets Single-cell RNA sequencing of human blood eosinophils reveals …

Eosinophils are key effector cells mediating airway inflammation and exacerbation in
patients with severe eosinophilic asthma. They are present in increased numbers and …

Asthma affects 25 million Americans, and recent advances in treatment are effective for only
a portion of severe asthma patients. TREM-1, an innate receptor that canonically amplifies …

Ulcerative colitis (UC) is a chronic disorder of the large intestine with inflammation and
ulceration. The incidence and prevalence of UC have been rapidly increasing worldwide …

Eosinophils function as inflammatory effectors in allergic diseases but also contribute to
tissue homeostasis in steady state. Emerging data are revealing tissue eosinophils to be …

Eosinophils are a highly abundant cell type in the gastrointestinal tract during homeostatic
conditions, where they have recently been reported to take on an activated phenotype …

The gastrointestinal tract harbors diverse microorganisms in the lumen. Epithelial cells
segregate the luminal microorganisms from immune cells in the lamina propria by …

In a recent study published in Nature, Gurtner and colleagues identify active eosinophils (A-
Eos) as eosinophil subset with antibacterial and immune regulatory functions during …

Eosinophils have been mainly studied in allergic diseases and parasitic infections.
Nonetheless, eosinophils accumulate in a variety of solid tumors, including colorectal …