Novel insights into the ontogeny of basophils
K Miyake, J Ito, H Karasuyama - Frontiers in Allergy, 2024 - frontiersin.org
Basophils are the least common granulocytes, accounting for< 1% of peripheral blood
leukocytes. In the last 20 years, analytical tools for mouse basophils have been developed …
leukocytes. In the last 20 years, analytical tools for mouse basophils have been developed …
[HTML][HTML] Does Eosinophil Heterogeneity Translate into Functional Diversity? A Review of the Evolving Paradigm of Eosinophil Heterogeneity in Asthma
This review provides an overview of evidence supporting the existence of distinct
homeostatic and inflammatory eosinophil subpopulations in health and disease. Particular …
homeostatic and inflammatory eosinophil subpopulations in health and disease. Particular …
[HTML][HTML] The helminth TGF-β mimic TGM4 is a modular ligand that binds CD44, CD49d and TGF-β receptors to preferentially target myeloid cells
SP Singh, DJ Smyth, K Cunningham, A Mukundan… - bioRxiv, 2023 - ncbi.nlm.nih.gov
The murine helminth parasite Heligmosomoides polygyrus expresses a family of modular
proteins which, replicating the functional activity of the immunomodulatory cytokine TGF-β …
proteins which, replicating the functional activity of the immunomodulatory cytokine TGF-β …
Eosinophil Depletion as a Potential Therapeutic Strategy in Acute and Chronic Intestinal Inflammation Based on a Dextran Sulfate Sodium Colitis Model
I Jacobs, S Deleu, J Cremer… - Inflammatory Bowel …, 2024 - academic.oup.com
Background A role for eosinophils in intestinal inflammation and fibrosis in the context of
inflammatory bowel disease has been suggested, yet the precise nature, whether causal or …
inflammatory bowel disease has been suggested, yet the precise nature, whether causal or …
[HTML][HTML] Host-pathogen interactions from a metabolic perspective: methods of investigation
C Demangel, L Surace - Microbes and Infection, 2023 - Elsevier
Abstract (50 words) Metabolism shapes immune homeostasis in health and disease. This
review presents the range of methods that are currently available to investigate the dialog …
review presents the range of methods that are currently available to investigate the dialog …
5-HT-treated mouse B cells alleviate ulcerative colitis via RIPK1: Insights from proteomic and phosphoproteomic analyses
X Zhang, M Rao, P Gao - Journal of Proteomics, 2024 - Elsevier
hydroxytryptamine (5-HT) exerts various physiological effects on the intestine through
different signaling pathways and molecular transmission mechanisms, including pro-and …
different signaling pathways and molecular transmission mechanisms, including pro-and …
Novel insights into the heterogeneity of FOXP3+ Treg cells in drug-induced allergic reactions through single-cell transcriptomics
W Shen, Y Liang, D Lv, N Xie - Immunologic Research, 2024 - Springer
This study uncovers the novel heterogeneity of FOXP3+ regulatory T (Treg) cells and their
pivotal role in modulating immune responses during drug-induced allergic reactions …
pivotal role in modulating immune responses during drug-induced allergic reactions …
Ally, adversary, or arbitrator? The context-dependent role of eosinophils in vaccination for respiratory viruses and subsequent breakthrough infections
LA Chang, M Schotsaert - 2024 - academic.oup.com
Eosinophils are a critical type of immune cell and central players in type 2 immunity. Existing
literature suggests that eosinophils also can play a role in host antiviral responses, typically …
literature suggests that eosinophils also can play a role in host antiviral responses, typically …
Administration of a bacterial lysate to the airway compartment is sufficient to inhibit allergen-induced lung eosinophilia in germ-free mice
AN Michael, O Pivniouk, PC Ezeh… - Journal of Leukocyte …, 2024 - academic.oup.com
The nexus between eosinophils and microbes is attracting increasing attention. We
previously showed that airway administration of sterile microbial products contained in dust …
previously showed that airway administration of sterile microbial products contained in dust …
Eosinophils promote CD8+ T cell memory generation to potentiate anti-bacterial immunity
J Zhou, J Liu, B Wang, N Li, J Liu, Y Han… - Signal Transduction and …, 2024 - nature.com
Memory CD8+ T cell generation is crucial for pathogen elimination and effective vaccination
against infection. The cellular and molecular circuitry that underlies the generation of …
against infection. The cellular and molecular circuitry that underlies the generation of …