Objective To assess the potential of autophagy in migraine pathogenesis. Background The
interplay between neurons and microglial cells is important in migraine pathogenesis …

One of the major obstacles confronting the formulation of a mechanistic understanding for
Alzheimer's disease (AD) is its immense complexity—a complexity that traverses the full …

Background Migraine is a disorder associated with neuropeptide release, pain and
inflammation. Tau protein has recently been linked to inflammatory diseases and can be …

Recently developed anti-migraine therapeutics targeting calcitonin gene-related peptide
(CGRP) signaling are effective, though their sites of activity remain elusive. Notably, the …

Background The pathogenesis of migraine remains unclear; however, a large body of
evidence supports the hypothesis that immunological mechanisms play a key role …

Migraine is a highly prevalent disease worldwide, imposing enormous clinical and economic
burdens on individuals and societies. Current treatments exhibit limited efficacy and …

Background Monoclonal antibodies directed against the neuropeptide calcitonin gene-
related peptide (CGRP) are effective in the prevention of chronic and frequent episodic …

Recurrent headaches, encompassing migraine and tension-type headaches, represent
prevalent conditions affecting individuals across different age groups, exerting a substantial …

BACKGROUND AND PURPOSE: Concentrations of calcitonin gene-related peptide, a
neuropeptide and potent endogenous vasodilator, are reportedly higher in patients with …

Abstract Purpose of Review Surgical deactivation of migraine trigger sites by extracranial
neurovascular decompression has produced encouraging results and challenged previous …