The role of serotonin in drug use and addiction
CP Müller, JR Homberg - Behavioural brain research, 2015 - Elsevier
The use of psychoactive drugs is a wide spread behaviour in human societies. The
systematic use of a drug requires the establishment of different drug use-associated …
systematic use of a drug requires the establishment of different drug use-associated …
5-HT receptors and reward-related behaviour: a review
DJ Hayes, AJ Greenshaw - Neuroscience & biobehavioral reviews, 2011 - Elsevier
Abstract The brain's serotonin (5-HT) system is key in the regulation of reward-related
behaviours, from eating and drinking to sexual activity. The complexity of studying this …
behaviours, from eating and drinking to sexual activity. The complexity of studying this …
New therapeutic opportunities for 5-HT2C receptor ligands in neuropsychiatric disorders
G Di Giovanni, P De Deurwaerdère - Pharmacology & therapeutics, 2016 - Elsevier
Abstract The 5-HT 2C receptor (R) displays a widespread distribution in the CNS and is
involved in the action of 5-HT in all brain areas. Knowledge of its functional role in the CNS …
involved in the action of 5-HT in all brain areas. Knowledge of its functional role in the CNS …
[HTML][HTML] The 5-HT2C receptor agonist lorcaserin reduces nicotine self-administration, discrimination, and reinstatement: relationship to feeding behavior and impulse …
GA Higgins, LB Silenieks, A Roßmann… - …, 2012 - nature.com
Abstract Lorcaserin ((1R)-8-chloro-1-methyl-2, 3, 4, 5-tetrahydro-1H-3-benzazepine HCl) is
a selective 5-HT 2C receptor agonist with clinical efficacy in phase-III obesity trials. Based on …
a selective 5-HT 2C receptor agonist with clinical efficacy in phase-III obesity trials. Based on …
Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system
F Berrendero, P Robledo, JM Trigo… - Neuroscience & …, 2010 - Elsevier
Nicotine is the primary component of tobacco that maintains the smoking habit and develops
addiction. The adaptive changes of nicotinic acetylcholine receptors produced by repeated …
addiction. The adaptive changes of nicotinic acetylcholine receptors produced by repeated …
[HTML][HTML] The role of the dorsal raphé nucleus in reward-seeking behavior
K Nakamura - Frontiers in integrative neuroscience, 2013 - frontiersin.org
Pharmacological experiments have shown that the modulation of brain serotonin levels has
a strong impact on value-based decision making. Anatomical and physiological evidence …
a strong impact on value-based decision making. Anatomical and physiological evidence …
[HTML][HTML] From obesity to substance abuse: therapeutic opportunities for 5-HT2C receptor agonists
GA Higgins, EM Sellers, PJ Fletcher - Trends in pharmacological sciences, 2013 - cell.com
The recent US Food and Drug Administration (FDA) approval of the serotonin (5-
hydroxytryptamine, 5-HT) 5-HT 2C receptor agonist lorcaserin for the treatment of obesity …
hydroxytryptamine, 5-HT) 5-HT 2C receptor agonist lorcaserin for the treatment of obesity …
[HTML][HTML] Activation of ventral tegmental area 5-HT2C receptors reduces incentive motivation
L Valencia-Torres, CM Olarte-Sánchez… - …, 2017 - nature.com
Obesity is primarily due to food intake in excess of the body's energetic requirements, intake
that is not only associated with hunger but also the incentive value of food. The 5 …
that is not only associated with hunger but also the incentive value of food. The 5 …
[HTML][HTML] Animal models of nicotine exposure: relevance to second-hand smoking, electronic cigarette use, and compulsive smoking
Much evidence indicates that individuals use tobacco primarily to experience the
psychopharmacological properties of nicotine and that a large proportion of smokers …
psychopharmacological properties of nicotine and that a large proportion of smokers …
MicroRNA profiling reveals new aspects of HIV neurodegeneration: caspase‐6 regulates astrocyte survival
F Noorbakhsh, R Ramachandran, N Barsby… - The FASEB …, 2010 - Wiley Online Library
MicroRNAs (miRNAs) are small noncoding RNA molecules, which are known to regulate
gene expression in physiological and pathological conditions. miRNA profiling was …
gene expression in physiological and pathological conditions. miRNA profiling was …