The use of psychoactive drugs is a wide spread behaviour in human societies. The
systematic use of a drug requires the establishment of different drug use-associated …

Abstract The brain's serotonin (5-HT) system is key in the regulation of reward-related
behaviours, from eating and drinking to sexual activity. The complexity of studying this …

Abstract The 5-HT 2C receptor (R) displays a widespread distribution in the CNS and is
involved in the action of 5-HT in all brain areas. Knowledge of its functional role in the CNS …

Abstract Lorcaserin ((1R)-8-chloro-1-methyl-2, 3, 4, 5-tetrahydro-1H-3-benzazepine HCl) is
a selective 5-HT 2C receptor agonist with clinical efficacy in phase-III obesity trials. Based on …

Nicotine is the primary component of tobacco that maintains the smoking habit and develops
addiction. The adaptive changes of nicotinic acetylcholine receptors produced by repeated …

Pharmacological experiments have shown that the modulation of brain serotonin levels has
a strong impact on value-based decision making. Anatomical and physiological evidence …

The recent US Food and Drug Administration (FDA) approval of the serotonin (5-
hydroxytryptamine, 5-HT) 5-HT 2C receptor agonist lorcaserin for the treatment of obesity …

Obesity is primarily due to food intake in excess of the body's energetic requirements, intake
that is not only associated with hunger but also the incentive value of food. The 5 …

Much evidence indicates that individuals use tobacco primarily to experience the
psychopharmacological properties of nicotine and that a large proportion of smokers …

MicroRNAs (miRNAs) are small noncoding RNA molecules, which are known to regulate
gene expression in physiological and pathological conditions. miRNA profiling was …