Bile acids (BAs) are a group of amphiphilic molecules consisting of a rigid steroid core
attached to a hydroxyl group with a varying number, position, and orientation, and a …

Steatotic liver disease (SLD) displays a dynamic and complex disease phenotype.
Consequently, the metabolic dysfunction-associated steatotic liver disease …

Nonalcoholic fatty liver disease (NAFLD) affects approximately 25% of the adult population
worldwide. This pathology can progress into end-stage liver disease with life-threatening …

Our understanding of nonalcoholic steatohepatitis (NASH) pathophysiology continues to
advance rapidly. Given the complexity of the pathogenesis of NASH, the field has moved …

Fibrotic remodelling is a highly conserved protective response to tissue injury and it is
essential for the maintenance of structural and functional tissue integrity. Also hepatic …

In humans, aging, triggers increased plasma concentrations of triglycerides, cholesterol, low-
density lipoproteins and lower capacity of high-density lipoproteins to remove cellular …

Nonalcoholic fatty liver disease (NAFLD), a chronic condition associated with metabolic
dysfunction and obesity, has reached epidemic proportions worldwide. Although early …

The objective of this study was to investigate the effect of dietary fatty acid (FA) composition
on bile acid (BA) metabolism in a pig model of NAFLD, by using a multiomics approach …

Human fibroblast growth factor 19 (FGF19) has become a potential therapeutic target for
metabolic-related diseases. However, the effects of FGF19 on obesity-induced bone loss …

Bile acid (BA) metabolism is an attractive therapeutic target in nonalcoholic fatty liver
disease (NAFLD). We aimed to investigate the effect of ilexsaponin A1 (IsA), a major …