The main protease (Mpro) plays a pivotal role in the replication of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) and is considered a highly conserved viral target …

While the COVID-19 pandemic seems to be on its decline, the unclear impacts of long-
COVID cases, breakthrough infections in immunocompromised individuals, vaccine …

Despite the fast development of vaccines, severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is still circulating and generating variants of concern (VoC) that escape the …

Based on previous large-scale in silico screening several factor Xa inhibitors were proposed
to potentially inhibit SARS-CoV-2 Mpro. In addition to their known anticoagulants activity this …

Early since the onset of the COVID-19 pandemic, the medical and scientific community were
aware of extra respiratory actions of SARS-CoV-2 infection. Endothelitis, hypercoagulation …

One aspect of COVID-19 (coronavirus disease 2019) that has now been clarified, is that
patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …

Infection with the SARS-CoV-2 virus (COVID-19 disease) can cause a wide range of clinical
situations–from an asymptomatic state to fatal outcomes. In cases of serious clinical …

The chymotrypsin-like cysteine protease (3CLpro, also known as main protease—Mpro) and
papain-like protease (PLpro) of severe acute respiratory syndrome coronavirus 2 (SARS …

Tackling COVID-19 requires halting virus proliferation and reducing viral complications in
humans. Papaya leaf extract (PLE) is well known for its ability to inhibit numerous viral …

Abstract The Main Protease (Mpro) plays a pivotal role in the replication of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and is considered a highly conserved …