Crystal engineering of pharmaceutical cocrystals in the discovery and development of improved drugs

G Bolla, B Sarma, AK Nangia - Chemical reviews, 2022 - ACS Publications
The subject of crystal engineering started in the 1970s with the study of topochemical
reactions in the solid state. A broad chemical definition of crystal engineering was published …

Technological innovations in photochemistry for organic synthesis: flow chemistry, high-throughput experimentation, scale-up, and photoelectrochemistry

L Buglioni, F Raymenants, A Slattery… - Chemical …, 2021 - ACS Publications
Photoinduced chemical transformations have received in recent years a tremendous amount
of attention, providing a plethora of opportunities to synthetic organic chemists. However …

Bayesian Self‐Optimization for Telescoped Continuous Flow Synthesis

AD Clayton, EO Pyzer‐Knapp, M Purdie… - Angewandte …, 2023 - Wiley Online Library
The optimization of multistep chemical syntheses is critical for the rapid development of new
pharmaceuticals. However, concatenating individually optimized reactions can lead to …

Protein‐based Nanoparticles: from Drug Delivery to Imaging, Nanocatalysis and Protein Therapy

J Kaltbeitzel, PR Wich - Angewandte Chemie International …, 2023 - Wiley Online Library
Proteins and enzymes are versatile biomaterials for a wide range of medical applications
due to their high specificity for receptors and substrates, high degradability, low toxicity, and …

Towards 4th industrial revolution efficient and sustainable continuous flow manufacturing of active pharmaceutical ingredients

CR Sagandira, S Nqeketo, K Mhlana, T Sonti… - Reaction Chemistry & …, 2022 - pubs.rsc.org
Continuous flow chemistry has opened a new paradigm in both the laboratory and
pharmaceutical industry. This review details the recently reported literature on continuous …

Multiphasic Continuous‐Flow Reactors for Handling Gaseous Reagents in Organic Synthesis: Enhancing Efficiency and Safety in Chemical Processes

AAH Laporte, TM Masson, SDA Zondag… - Angewandte …, 2024 - Wiley Online Library
The use of reactive gaseous reagents for the production of active pharmaceutical
ingredients (APIs) remains a scientific challenge due to safety and efficiency limitations. The …

Process analytical technologies and self-optimization algorithms in automated pharmaceutical continuous manufacturing

P Liu, H Jin, Y Chen, D Wang, H Yan, M Wu… - Chinese Chemical …, 2023 - Elsevier
The pharmaceutical industry is now paying increased attention to continuous manufacturing.
While the revolution to continuous and automated manufacturing is deepening in most of the …

[HTML][HTML] Synergy of visible-light responsive photocatalytic materials and device engineering for energy and environment: Minireview on hydrogen production and …

P Jiménez-Calvo - Materials Today Catalysis, 2024 - Elsevier
Accelerated advances in photocatalysis demand alignment with a well-defined Technology
Readiness Levels (TRLs) roadmap to overcome bottlenecks and attain TRLs of 3 or beyond …

Continuous Flow Chemistry with Solids: A Review

HLD Hayes, CJ Mallia - Organic Process Research & …, 2024 - ACS Publications
The effective handling of solids in a continuous flow process is one of the biggest perceived
challenges remaining for modern flow chemistry. This Review aims to consider some of the …

Tackling current production of HAp and HAp-driven biomaterials

A Veiga, S Madureira, JB Costa, F Castro… - Materials …, 2023 - pubs.rsc.org
Hydroxyapatite (HAp)-based biomaterials are well-established for biomedical applications
due to their extensive research work and clinical track record. Recent efforts have been …