The RNA-binding protein fused-in-sarcoma (FUS) has been associated with amyotrophic
lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), two …

Fused in sarcoma (FUS) is a nuclear DNA/RNA binding protein that regulates different steps
of gene expression, including transcription, splicing and mRNA transport. FUS has been …

Fused in sarcoma (FUS) is a ubiquitously expressed RNA‐binding protein proposed to
function in various RNA metabolic pathways, including transcription regulation, pre‐mRNA …

Background Amyotrophic lateral sclerosis (ALS)-linked fused in sarcoma/translocated in
liposarcoma (FUS/TLS or FUS) is concentrated within cytoplasmic stress granules under …

Fused in sarcoma (FUS), identified as the heterogeneous nuclear ribonuclear protein P2, is
expressed in neuronal and non-neuronal tissue, and among other functions, has been …

The heterogeneous nuclear ribonucleoproteins (hnRNP) are a family of proteins which
share common structural domains, and extensive research has shown that they have central …

MicroRNA-mediated gene silencing is a fundamental mechanism in the regulation of gene
expression. It remains unclear how the efficiency of RNA silencing could be influenced by …

Dominant mutations in FUS/TLS cause a familial form of amyotrophic lateral sclerosis (fALS),
where abnormal accumulation of mutant FUS proteins in cytoplasm has been observed as a …

In this review, the role of aberrant RNA metabolism in ALS is examined, including the
evidence that a majority of the genetic mutations observed in familial ALS (including …

Fused in sarcoma/translocated in liposarcoma (FUS/TLS or FUS) is a multifunctional DNA-
/RNA-binding protein that is involved in a variety of cellular functions including transcription …