The loss of synapses is a central event in neurodegenerative diseases. Synaptic proteins
are often associated with disease neuropathology, but their role in synaptic loss is not fully …

Mutations in the gene encoding fused in sarcoma (FUS) were recently identified as a novel
cause of amyotrophic lateral sclerosis (ALS), emphasizing the genetic heterogeneity of ALS …

Fused in sarcoma (FUS) is a DNA/RNA binding protein that is involved in RNA metabolism
and DNA repair. Numerous reports have demonstrated by pathological and genetic analysis …

Neurodegenerative disorders such as Alzheimer disease (AD), frontotemporal dementia
(FTD), amyotrophic lateral sclerosis (ALS), Parkinson disease (PD), Huntington's disease …

TLS (translocated in liposarcoma), also known as FUS (fused in sarcoma), is an RNA/DNA-
binding protein that plays regulatory roles in transcription, pre-mRNA splicing and mRNA …

Objective To determine the frequency of and clinicopathologic phenotypes associated
withFUS/TLSmutations in a large cohort of amyotrophic lateral sclerosis (ALS) cases from …

Dominant mutations and mislocalization or aggregation of Fused in Sarcoma (FUS), an RNA-
binding protein (RBP), cause neuronal degeneration in Amyotrophic Lateral Sclerosis (ALS) …

The fused in sarcoma (FUS) protein combines prion-like properties with a multifunctional
DNA/RNA-binding domain and has functions spanning the regulation of RNA metabolism …

The amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)–linked RNA-
binding protein called FUS (fused in sarcoma) has been implicated in several aspects of …

Protein homeostasis, or proteostasis, has an important regulatory role in cellular function.
Protein quality control mechanisms, including protein folding and protein degradation …