Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by the premature loss of
motor neurons. While the underlying cellular mechanisms of neuron degeneration are …

RNA granules are microscopically visible cellular structures that aggregate by protein–
protein and protein–RNA interactions. Using stress granules as an example, we discuss the …

Mutations in the FUS gene cause amyotrophic lateral sclerosis (ALS-FUS). However, the
exact pathogenic mechanism of mutant fused in sarcoma (FUS) protein is not completely …

Mutations in the fused in sarcoma/translated in liposarcoma gene (FUS/TLS, FUS) have
been identified in sporadic and familial forms of amyotrophic lateral sclerosis (ALS). FUS is …

Five structurally and functionally different proteins, an enzyme superoxide dismutase 1
(SOD1), a TAR-DNA binding protein-43 (TDP-43), an RNA-binding protein FUS, a cofilin …

The alternative splicing of mRNA is a critical process in higher eukaryotes that generates
substantial proteomic diversity. Many of the proteins that are essential to this process contain …

Antisense oligonucleotides (ASOs) are versatile tools that can regulate multiple steps of
RNA biogenesis in cells and living organisms. Significant improvements in delivery, potency …

Fused in sarcoma (FUS) is involved in many processes of RNA metabolism. FUS and
another RNA binding protein, TDP-43, are implicated in amyotrophic lateral sclerosis (ALS) …

SOX2 is a key gene implicated in maintaining the stemness of embryonic and adult stem
cells that appears to re‐activate in several human cancers including glioblastoma …

Amyotrophic lateral sclerosis and frontotemporal dementia form two poles of a genetically,
pathologically and clinically-related disease continuum. Analysis of the genes and proteins …