Abstract GGGGCC (G4C2) hexanucleotide repeat expansion (HRE) in the first intron of the
chromosome 9 open reading frame 72 (C9ORF72) gene is the most common genetic cause …

The vertebrate intestine is a model for investigating inductive cellular interactions and the
roles of epithelial stem cells in tissue regeneration, and for understanding parallels between …

Motor neuron diseases (MNDs) are rare and frequently fatal neurological disorders in which
motor neurons within the brainstem and spinal cord regions slowly die. MNDs are primarily …

Recently, the fused in sarcoma/translated in liposarcoma (FUS) protein has been identified
as a major constituent of nuclear and/or cytoplasmic ubiquitin-positive inclusions in patients …

Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease
that affects upper and lower motor neurons. Familial ALS accounts for a small subset of …

Pathological alteration of TDP-43 (TAR DNA-binding protein-43), a protein involved in
various RNA-mediated processes, is a hallmark feature of the neurodegenerative diseases …

NKAP is a highly conserved protein with roles in transcriptional repression, T-cell
development, maturation and acquisition of functional competency and maintenance and …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder lacking
effective treatments. ALS pathology is linked to mutations in several different genes …

Abstract Mutations in Fused in Sarcoma (FUS) are present in familial and sporadic cases of
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). FUS is localised in …

Fused in sarcoma (FUS) is an RNA‐binding protein that is causally associated with
oncogenesis and neurodegeneration. Recently, the role of FUS in neurodegeneration has …