Background Vagus nerve stimulation (VNS) is an established therapy for treating a variety of
chronic diseases, such as epilepsy, depression, obesity, and for stroke rehabilitation …

Abstract Background and Aims The spleen serves as an important relay organ that releases
cardioprotective factor (s) upon vagal activation during remote ischaemic conditioning (RIC) …

Acute myocardial infarction (AMI) is associated with high morbidity and mortality worldwide.
Although early reperfusion is the most effective strategy to salvage ischemic myocardium …

Introduction Inflammation is an inherently self-amplifying process, resulting in progressive
tissue damage when unresolved. A brake on this positive feedback system is provided by …

Afferent and efferent fibers in the vagus nerve travel inside fascicles and form branches to
innervate organs and regulate organ functions. The spatial organization of fibers and …

Background Reduced heart rate (HR) during vagus nerve stimulation (VNS) is associated
with therapy for heart failure, but stimulation frequency and amplitude are limited by patient …

Objective. In nerve stimulation therapies, fibers in larger fascicles generally have higher
activation thresholds, but the mechanisms are not well understood. We implemented and …

Interfacing with the peripheral nervous system is a powerful method for diagnosing and
treating several diseases, such as drug‐resistant epilepsy and depression. In most clinical …

The vagus nerve regulates inflammation and cytokine release through the inflammatory
reflex. Recent pilot clinical trials using implantable bioelectronic devices have demonstrated …

Objective. Intraneural nerve interfaces often operate in a monopolar configuration with a
common and distant ground electrode. This configuration leads to a wide spreading of the …