Emerging evidence indicates that the detection and clearance of cancer cells via
phagocytosis induced by innate immune checkpoints play significant roles in tumor …

The immune checkpoint pathway consisting of the cell membrane-bound molecule
programmed death protein 1 (PD-1) and its ligand PD-L1 has been found to mediate …

Background Our previous work showed that the anti-TGF-β/PD-L1 bispecific antibody
YM101 effectively overcame anti-PD-L1 resistance in immune-excluded tumor models …

In the last ten years, it has become increasingly clear that tumor-infiltrating myeloid cells
drive not just carcinogenesis via cancer-related inflammatory processes, but also tumor …

Background Recently, therapeutic antibodies against programmed cell death 1 (PD-1) and
its ligand (PD-L1) have exerted potent anticancer effect in a variety of tumors. However …

Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are clonal
hematopoietic stem cell diseases arising from the bone marrow (BM), and approximately …

Tumor microenvironment (TME) is a crucial regulator of tumor progression and cells in the
TME release a number of molecules that are responsible for anaplasticity, invasion …

The Kelch-like ECH-associated protein 1/nuclear factor erythroid-derived 2-like 2
(KEAP1/NRF2) pathway is well recognized as a key regulator of redox homeostasis …

Abstract Background Tumor-associated macrophages (TAMs) promote key processes in the
modulation of tumor microenvironment (TME). However, the clinical significance of …

Hepatocellular carcinoma (HCC) is one of the common and fatal malignancies, which is a
significant global health problem. The clinical applicability of traditional surgery and other …