The insulin receptor (IR) gene undergoes differential splicing that generates two IR isoforms,
IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and …

Colorectal cancer (CRC) is one of the most common aggressive carcinoma types worldwide,
characterized by unfavorable curative effect and poor prognosis. Epidemiological data re …

Alzheimer's disease (AD) should be regarded as a degenerative metabolic disease caused
by brain insulin resistance and deficiency, and overlapping with the molecular, biochemical …

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
worldwide and its incidence is definitely increasing. NAFLD is a metabolic disease with …

The general spread of Tribulus terrestris L.(South Africa, Australia, Europe, and India), the
high content of active ingredients (in particular sterol saponins, as well as flavonoids …

Lipodystrophies have been recognized since at least the nineteenth century and, despite
their rarity, tended to attract considerable medical attention because of the severity and …

Objective A decline in mitochondrial function and biogenesis as well as increased reactive
oxygen species (ROS) are important determinants of aging. With advancing age, there is a …

Cancer cachexia is a complex disorder that is driven by inflammation and metabolic
imbalances, resulting in extreme weight loss. Adipose tissue, a main player in cancer …

Benign prostate hyperplasia (BPH), one of the most common diseases in older men,
adversely affects quality-of-life due to the presence of low urinary tract symptoms (LUTS) …

Tendon injuries suffer from a slow healing, often ending up in fibrovascular scar formation,
leading to inferior mechanical properties and even re-rupture upon resumption of daily work …