Narcotics reduce the behavioral response to injury, while leaving unaffected the response to
other stimuli. This effect could be due to a reduction of the central transmission of injury …

Cholinergic systems have been linked to cognitive processes such as attention, learning
and mnemonic function. However, other neurotransmitter systems, such as the serotonergic …

Experiments were carried out in rats to (1) elaborate upon the specificity of drug action in the
periaqueductal gray matter (PAG), and (2) to evaluate the possible congruence of PAG sites …

Experimental evidence is reviewed showing that brain and spinal cord serotonergic neurons
are involved in nociceptive responses, as well as in the analgesic effects of opiate narcotics …

Lesions were produced in either the dorsal or median raphe nucleus and regional 5-
hydroxytryptamine (5-HT), 5-hydroxyindole acetic acid (5-HIAA), and norepinephrine (NE) …

Lesions were produced in the median (n= 8), dorsal (n= 7) or both (n= 7) midbrain raphe
nuclei and their effects on behavior (days 16–54 postoperatively) compared to that of …

Two-way active avoidance (TWAA) acquisition constitutes a particular case of approach–
avoidance conflict for laboratory rodents. The present article reviews behavioural …

Drugs have been utilized for many years as experimental tools in the analysis of the
biological mechanisms underlying behavior. An assumption implicit in this approach is that …

The electrolytic brain lesion technique was used to interrupt the ascending serotonergic
pathways at the level of the midbrain raphé nuclei in order to determine the role of 5 …

Summary In protriptyline (25 mg/kg) pretreated rats stereotactic 5, 7-dihydroxytryptamine (5,
7-DHT) lesions of the medial plus lateral 5-hydroxytryptamine (5-HT) bundles in the …