Melatonin is ubiquitous molecule with wide distribution in nature and is produced by many
living organisms. In human beings, pineal gland is the major site for melatonin production …

Many processes in the human body—including brain function—are regulated over the 24-
hour cycle, and there are strong associations between disrupted circadian rhythms (for …

Background: Melatonin synchronizes central but also peripheral oscillators (fetal adrenal
gland, pancreas, liver, kidney, heart, lung, fat, gut, etc.), allowing temporal organization of …

Melatonin is an old and ubiquitous molecule in nature showing multiple mechanisms of
action and functions in practically every living organism. In mammals, pineal melatonin …

The aim of this review is to summarize the key findings from genetic and epidemiological
research, which show that autism is a complex disorder resulting from the combination of …

Study Objectives: Melatonin is an important neurohormone, which mediates circadian
rhythms and the sleep cycle. As such, it is a popular and readily available supplement for the …

Pro-inflammatory systemic conditions that can cause neuroinflammation and subsequent
alterations in brain regions involved in emotional regulation have been suggested as an …

The role of serotonin (5-HT) in sleep is controversial: early studies suggested a sleep-
promoting role, but eventually the paradigm shifted toward a wake-promoting function for the …

The hormone melatonin (5-methoxy-N-acetyltryptamine) is synthesized primarily in the
pineal gland and retina, and in several peripheral tissues and organs. In the circulation, the …

Daily rhythms in physiological and behavioral processes are controlled by a network of
circadian clocks, reset by inputs and delivering circadian signals to the brain and peripheral …