Physiological‐based pharmacokinetic modeling trends in pharmaceutical drug development over the last 20‐years; in‐depth analysis of applications, organizations …
E El‐Khateeb, S Burkhill, S Murby… - … & Drug Disposition, 2021 - Wiley Online Library
We assess the advancement of physiologically based pharmacokinetic (PBPK) modeling
and simulation (M&S) over the last 20 years (start of 2000 to end of 2019) focusing on the …
and simulation (M&S) over the last 20 years (start of 2000 to end of 2019) focusing on the …
Evaluation of pharmacokinetic drug–drug interactions: a review of the mechanisms, in vitro and in silico approaches
Y Peng, Z Cheng, F Xie - Metabolites, 2021 - mdpi.com
Pharmacokinetic drug–drug interactions (DDIs) occur when a drug alters the absorption,
transport, distribution, metabolism or excretion of a co-administered agent. The occurrence …
transport, distribution, metabolism or excretion of a co-administered agent. The occurrence …
Non-uniformity of changes in drug-metabolizing enzymes and transporters in liver cirrhosis: implications for drug dosage adjustment
Liver cirrhosis is a chronic disease that affects the liver structure, protein expression, and
overall metabolic function. Abundance data for drug-metabolizing enzymes and transporters …
overall metabolic function. Abundance data for drug-metabolizing enzymes and transporters …
The first-in-human whole-body dynamic pharmacokinetics study of aptamer
Serving as targeting ligands, aptamers have shown promise in precision medicine.
However, the lack of knowledge of the biosafety and metabolism patterns in the human body …
However, the lack of knowledge of the biosafety and metabolism patterns in the human body …
Quantitative proteomics in translational absorption, distribution, metabolism, and excretion and precision medicine
A reliable translation of in vitro and preclinical data on drug absorption, distribution,
metabolism, and excretion (ADME) to humans is important for safe and effective drug …
metabolism, and excretion (ADME) to humans is important for safe and effective drug …
Reviewing data integrated for PBPK model development to predict metabolic drug-drug interactions: shifting perspectives and emerging trends
K Abouir, CF Samer, Y Gloor, JA Desmeules… - Frontiers in …, 2021 - frontiersin.org
Physiologically-based pharmacokinetics (PBPK) modeling is a robust tool that supports drug
development and the pharmaceutical industry and regulatory authorities. Implementation of …
development and the pharmaceutical industry and regulatory authorities. Implementation of …
A systematic review of published physiologically-based kinetic models and an assessment of their chemical space coverage
CV Thompson, JW Firman… - Alternatives to …, 2021 - journals.sagepub.com
Across multiple sectors, including food, cosmetics and pharmaceutical industries, there is a
need to predict the potential effects of xenobiotics. These effects are determined by the …
need to predict the potential effects of xenobiotics. These effects are determined by the …
In-depth analysis of physiologically based pharmacokinetic (PBPK) modeling utilization in different application fields using text mining tools
In the past decade, only a small number of papers have elaborated on the application of
physiologically based pharmacokinetic (PBPK) modeling across different areas. In this …
physiologically based pharmacokinetic (PBPK) modeling across different areas. In this …
Pediatric drug‐drug interaction evaluation: drug, patient population, and methodological considerations
D Gonzalez, J Sinha - The Journal of Clinical Pharmacology, 2021 - Wiley Online Library
Hospitalized pediatric patients and those with complex or chronic conditions treated on an
outpatient basis are commonly prescribed multiple drugs, resulting in increased risk for drug …
outpatient basis are commonly prescribed multiple drugs, resulting in increased risk for drug …
Physiologically based pharmacokinetic (PBPK) model-informed dosing guidelines for pediatric clinical care: a pragmatic approach for a special population
JJM Freriksen, JEM van der Heijden… - Pediatric Drugs, 2023 - Springer
Physiologically based pharmacokinetic (PBPK) modeling can be an attractive tool to
increase the evidence base of pediatric drug dosing recommendations by making optimal …
increase the evidence base of pediatric drug dosing recommendations by making optimal …