The facultative intracellular bacterium Listeria (L.) monocytogenes may cause severe
diseases in humans and animals. The control of listeriosis/L. monocytogenes requires the …

CD19-targeting chimeric antigen receptors (CARs) with CD28 and CD3ζ signaling domains
have been approved by the US FDA for treating B cell malignancies. Mutation of …

Dissolved oxygen (DO) is essential for teleosts, and fluctuating environmental factors can
result in hypoxic stress in the golden pompano (Trachinotus blochii). However, it is unknown …

Abstract CD28 and 4-1BB costimulatory endodomains included in chimeric antigen receptor
(CAR) molecules play a critical role in promoting sustained antitumor activity of CAR-T cells …

Although most patients with thyroid cancers have good prognosis and long-term survival,
some patients are refractory to traditional therapeutic approaches and face a high risk of …

Objectives: Approximately 240 million individuals are infected with chronic hepatitis B virus
(HBV) worldwide. HBV infection can develop into liver fibrosis. The mechanism of HBV …

Purpose The mitogen-activated protein kinase (MAPK) signaling pathway is often studied in
oncology as the most easily mentioned signaling pathway. This study aims to establish a …

Memory CD8+ T cell generation is crucial for pathogen elimination and effective vaccination
against infection. The cellular and molecular circuitry that underlies the generation of …

The versatile intracellular adaptor protein Tumor necrosis factor receptor (TNFR) associated
factor 3 (TRAF3) plays an important role in T cell biology. Mice with T cell-specific TRAF3 …

Type 2 inflammation of the airways is present in most patients with asthma, and some
patients with chronic obstructive pulmonary disease (COPD). The molecular drivers of the …