The excessive formation of reactive oxygen species (ROS) and impairment of defensive
antioxidant systems leads to a condition known as oxidative stress. The main source of free …

Melatonin is an ancient molecule that originated in bacteria. When these prokaryotes were
phagocytized by early eukaryotes, they eventually developed into mitochondria and …

The health benefits of regular exercise are well established. Nonetheless, the molecular
mechanism (s) responsible for exercise-induced health benefits remain a topic of debate …

Abstract Sirtuin-3 (SIRT3), the main deacetylase in the mitochondria, maintains cellular
energy metabolism and redox balance by deacetylating mitochondrial proteins in a NAD+ …

Osteoarthritis (OA) is mainly characterized by the progressive destruction of articular
cartilage. Mounting studies have revealed that disruption of extracellular matrix (ECM) …

Background The aim of this study was to investigate the biological functions and underlying
mechanisms of SIRT5 in clear cell renal cell carcinoma (ccRCC). Methods SIRT5 expression …

Obesity is a major current public health problem of global significance. A progressive sperm
quality decline, and a decline in male fertility, have been reported in recent decades …

Follicular microenvironment is paramount in the acquisition of oocyte competence, which is
dependent on two interconnected and interdependent processes: nuclear and cytoplasmic …

We investigated the mechanism by which quercetin preserves mitochondrial quality control
(MQC) in cardiomyocytes subjected to ischemia–reperfusion stress. An enzyme‐linked …

Recently, the importance of bioenergetics in the reproductive process has emerged. For its
energetic demand, the oocyte relies on numerous mitochondria, whose activity increases …