DNA methylation-based testing in liquid biopsies as detection and prognostic biomarkers for the four major cancer types

V Constâncio, SP Nunes, R Henrique, C Jerónimo - Cells, 2020 - mdpi.com
Lung, breast, colorectal, and prostate cancers are the most incident worldwide. Optimal
population-based cancer screening methods remain an unmet need, since cancer detection …

Bridging the gaps between circulating tumor cells and DNA methylation in prostate cancer

BCT Flores, MP Correia, JG Rodriguez, R Henrique… - Cancers, 2021 - mdpi.com
Prostate cancer is the second most common male malignancy, with a highly variable clinical
presentation and outcome. Therefore, diagnosis, prognostication, and management remain …

[HTML][HTML] DNA methylation regulates alternative polyadenylation via CTCF and the cohesin complex

V Nanavaty, EW Abrash, C Hong, S Park, EE Fink, Z Li… - Molecular cell, 2020 - cell.com
Dysregulation of DNA methylation and mRNA alternative cleavage and polyadenylation
(APA) are both prevalent in cancer and have been studied as independent processes. We …

Known epigenetic biomarkers for prostate cancer detection and management: Exploring the potential of blood-based liquid biopsies

V Constâncio, D Barros-Silva, C Jerónimo… - Expert Review of …, 2019 - Taylor & Francis
ABSTRACT Introduction: Although prostate cancer (PCa) stands as an important cause of
cancer-related deaths, a sizeable proportion of diagnosed cases are clinically insignificant …

[HTML][HTML] Cell-free DNA in the management of prostate cancer: Current status and future prospective

W He, Y Xiao, S Yan, Y Zhu, S Ren - Asian Journal of Urology, 2023 - Elsevier
Objective With the escalating prevalence of prostate cancer (PCa) in China, there is an
urgent demand for novel diagnostic and therapeutic approaches. Extensive investigations …

Integrated analysis to identify the AC005154. 6/hsa-miR-29c-3p/CCNL2 axis as a novel prognostic biomarker associated with immune infiltration in prostate cancer

Q Li, B Chen, G Song, K Zeng, X Chen, J Miao… - Cancer cell …, 2022 - Springer
Abstract Background Prostate cancer (PCa) is currently the major malignancy in men. It is
becoming increasingly clear that competitive endogenous RNA (ceRNA) regulation …

The role of alternative polyadenylation in cancer progression

BP Jain - Gene Reports, 2018 - Elsevier
Regulation of gene expression is attributed at multiple levels as transcriptional, post-
transcriptional and post-translational events. Under various modes of post-transcriptional …

Obesity, diabetes mellitus, and cancer

WW de Herder, C Eng - Endocrine-related cancer, 2012 - erc.bioscientifica.com
It happened in Pittsburgh, Pennsylvania, USA, in the year 2000. Bora Baysal, MD, PhD, a
Turkish molecular biologist and trained pathologist, collaborated with physicians from …

[PDF][PDF] Cell-free DNA methylation as a biomarker for early detecting the four major cancers

TB da Rocha - 2022 - repositorio-aberto.up.pt
Introdução: Os cancros da mama (CaMa), pulmão (CaPl), coloretal (CaCr) e próstata (CaP)
são os quatro cancros mais incidentes a nível mundial para ambos os sexos. Apesar de os …

Cell-free DNA methylation as a biomarker for early detection of the three major cancers in males

VIS Constâncio - 2019 - search.proquest.com
Introdução: Os cancros do pulmão (CaPl), próstata (CaP) e coloretal (CaCr) são os três mais
incidentes no sexo masculino a nível mundial. Apesar dos avanços científicos, a procura de …