The clinical pharmacogenetics implementation consortium: 10 years later

MV Relling, TE Klein, RS Gammal… - Clinical …, 2020 - Wiley Online Library
In 2009, the Clinical Pharmacogenetics Implementation Consortium (CPIC, www. cpicpgx.
org), a shared project between Pharmacogenomics Knowledge Base (PharmGKB …

Translating pharmacogenomics into clinical decisions: do not let the perfect be the enemy of the good

K Krebs, L Milani - Human genomics, 2019 - Springer
The field of pharmacogenomics (PGx) is gradually shifting from the reactive testing of single
genes toward the proactive testing of multiple genes to improve treatment outcomes, reduce …

Standardizing CYP2D6 Genotype to Phenotype Translation: Consensus Recommendations from the Clinical Pharmacogenetics Implementation Consortium and …

KE Caudle, K Sangkuhl, M Whirl‐Carrillo… - Clinical and …, 2020 - Wiley Online Library
Translating CYP 2D6 genotype to metabolizer phenotype is not standardized across clinical
laboratories offering pharmacogenetic (PGx) testing and PGx clinical practice guidelines …

[HTML][HTML] Recommendations for clinical CYP2D6 genotyping allele selection: a joint consensus recommendation of the Association for Molecular Pathology, College of …

VM Pratt, LH Cavallari, AL Del Tredici… - The Journal of Molecular …, 2021 - Elsevier
The goals of the Association for Molecular Pathology Clinical Practice Committee's
Pharmacogenomics (PGx) Working Group are to define the key attributes of …

Genophenotypic factors and pharmacogenomics in adverse drug reactions

R Cacabelos, V Naidoo, L Corzo, N Cacabelos… - International journal of …, 2021 - mdpi.com
Adverse drug reactions (ADRs) rank as one of the top 10 leading causes of death and
illness in developed countries. ADRs show differential features depending upon genotype …

Barriers to clinical adoption of pharmacogenomic testing in psychiatry: a critical analysis

CR Virelli, AG Mohiuddin, JL Kennedy - Translational psychiatry, 2021 - nature.com
Pharmacogenomics (PGx) is the study of genetic influences on an individual's response to
medications. Improvements in the quality and quantity of PGx research over the past two …

ASHP statement on the pharmacist's role in clinical pharmacogenomics

CE Haidar, N Petry, C Oxencis… - American Journal of …, 2022 - academic.oup.com
Background Clinical pharmacogenomics uses genetic information to guide optimal drug
selection and drug dosing for patients to maximize therapeutic effects, improve outcomes …

Development of the PG x‐Passport: a panel of actionable germline genetic variants for pre‐emptive pharmacogenetic testing

CH van der Wouden, MH van Rhenen… - Clinical …, 2019 - Wiley Online Library
Pre‐emptive pharmacogenetics (PG x) testing of a panel of germline genetic variants
represents a new model for personalized medicine. Clinical impact of PG x testing is …

Moving pharmacogenetics into practice: it's all about the evidence!

JA Luzum, N Petry, AK Taylor… - Clinical …, 2021 - Wiley Online Library
The evidence for pharmacogenetics has grown rapidly in recent decades. However, the
strength of evidence required for the clinical implementation of pharmacogenetics is highly …

Advancing pharmacogenomics from single-gene to preemptive testing

CE Haidar, KR Crews, JM Hoffman… - Annual review of …, 2022 - annualreviews.org
Pharmacogenomic testing can be an effective tool to enhance medication safety and
efficacy. Pharmacogenomically actionable medications are widely used, and approximately …