Broadly neutralizing antibodies targeting HIV: Progress and challenges
Anti-HIV broadly neutralizing antibodies (bNAbs) offer a novel approach to treating,
preventing, or curing HIV. Pre-clinical models and clinical trials involving the passive transfer …
preventing, or curing HIV. Pre-clinical models and clinical trials involving the passive transfer …
Mapping the interplay between NK cells and HIV: therapeutic implications
RR Anderko, RB Mailliard - Journal of leukocyte biology, 2023 - academic.oup.com
Although highly effective at durably suppressing plasma HIV-1 viremia, combination
antiretroviral therapy (ART) treatment regimens do not eradicate the virus, which persists in …
antiretroviral therapy (ART) treatment regimens do not eradicate the virus, which persists in …
[HTML][HTML] Multimeric immunotherapeutic complexes activating natural killer cells towards HIV-1 cure
R Schober, B Brandus, T Laeremans… - Journal of Translational …, 2023 - Springer
Background Combination antiretroviral therapy (cART) has dramatically extended the life
expectancy of people living with HIV-1 and improved their quality of life. There is …
expectancy of people living with HIV-1 and improved their quality of life. There is …
[HTML][HTML] Activin A, a novel chemokine, induces mouse NK cell migration via AKT and calcium signaling
Y Wang, Z Liu, Y Qi, J Wu, B Liu, X Cui - Cells, 2024 - mdpi.com
Natural killer (NK) cells can migrate quickly to the tumor site to exert cytotoxic effects on
tumors, and some chemokines, including CXCL8, CXCL10 or and CXCL12, can regulate the …
tumors, and some chemokines, including CXCL8, CXCL10 or and CXCL12, can regulate the …
[HTML][HTML] Targeting HIV persistence in the tissue
DKJ Pieren, A Benítez-Martínez… - Current Opinion in HIV …, 2024 - journals.lww.com
Targeting persistence in tissue reservoirs represents a complex but essential step towards
achieving HIV cure. Combinatorial strategies, particularly during the early phases of …
achieving HIV cure. Combinatorial strategies, particularly during the early phases of …
[HTML][HTML] Autologous dendritic cell vaccination against HIV-1 induces changes in natural killer cell phenotype and functionality
T Laeremans, S Den Roover, C Lungu, S D'haese… - npj Vaccines, 2023 - nature.com
Although natural killer (NK) cells have been studied in connection with dendritic cell (DC)-
based vaccination in the field of cancer immunology, their role has barely been addressed in …
based vaccination in the field of cancer immunology, their role has barely been addressed in …
[HTML][HTML] Efficacy and safety of novel multifunctional M10 CAR-T cells in HIV-1-infected patients: a phase I, multicenter, single-arm, open-label study
Y Mao, Q Liao, Y Zhu, M Bi, J Zou, N Zheng, L Zhu… - Cell Discovery, 2024 - nature.com
Chimeric antigen receptor T (CAR-T) cells have been proposed for HIV-1 treatment but have
not yet demonstrated desirable therapeutic efficacy. Here, we report newly developed anti …
not yet demonstrated desirable therapeutic efficacy. Here, we report newly developed anti …
[HTML][HTML] KDM5A/B contribute to HIV-1 latent infection and survival of HIV-1 infected cells
TW Li, Y Park, EG Watters, X Wang, D Zhou… - Antiviral Research, 2024 - Elsevier
Combinational antiretroviral therapy (cART) suppresses human immunodeficiency virus type
1 (HIV-1) viral replication and pathogenesis in acquired immunodeficiency syndrome (AIDS) …
1 (HIV-1) viral replication and pathogenesis in acquired immunodeficiency syndrome (AIDS) …
[HTML][HTML] Effective innate immune response in natural HIV-1 controllers. Can mimicking lead to novel preventive and cure strategies against HIV-1?
M Calvet-Mirabent, E Martín-Gayo - Current Opinion in HIV and …, 2022 - journals.lww.com
Effective innate immune response in natural HIV-1 controller... : Current Opinion in HIV and
AIDS Effective innate immune response in natural HIV-1 controllers. Can mimicking lead to …
AIDS Effective innate immune response in natural HIV-1 controllers. Can mimicking lead to …
Harnessing natural killer cells to target HIV-1 persistence
VR Joshi, M Altfeld - Current Opinion in HIV and AIDS, 2024 - journals.lww.com
Numerous studies focusing on targeting latently HIV-1-infected cells have emphasized a
potential role of NK cells in these strategies. Our review highlights recent advances in …
potential role of NK cells in these strategies. Our review highlights recent advances in …