Recent progress of interferon-tau research and potential direction beyond pregnancy recognition

H Bai, M Kawahara, M Takahashi… - Journal of Reproduction …, 2022 - jstage.jst.go.jp
Since the discovery of interferon-tau (IFNT) over 30 years ago as the trophectodermal
cytokine responsible for the maintenance of the maternal corpus luteum (CL) in ruminants …

[HTML][HTML] Effects of miR-98 in intrauterine extracellular vesicles on maternal immune regulation during the peri-implantation period in cattle

K Nakamura, K Kusama, A Ideta, K Kimura, M Hori… - Scientific reports, 2019 - nature.com
Evidence accumulated suggests that extracellular vesicles (EVs) present in uterine lumen
play a role in conceptus-endometrial cell interactions during peri-implantation periods …

Intrauterine exosomes are required for bovine conceptus implantation

K Kusama, K Nakamura, R Bai, K Nagaoka… - Biochemical and …, 2018 - Elsevier
Exosomes, extracellular vesicles, are present in uterine flushing fluids (UFs), which are
involved in conceptus-endometrial interactions during peri-implantation periods. Despite …

Human endometrial transcriptome and progesterone receptor cistrome reveal important pathways and epithelial regulators

RA Chi, T Wang, N Adams, S Wu… - The Journal of …, 2020 - academic.oup.com
Context Poor uterine receptivity is one major factor leading to pregnancy loss and infertility.
Understanding the molecular events governing successful implantation is hence critical in …

Transforming growth factor-β superfamily and interferon-τ in ovarian function and embryo development in female cattle: review of biology and application

JD Michael, G Campanile… - Reproduction, Fertility and …, 2020 - CSIRO Publishing
Survival of the embryo and establishment of a pregnancy is a critical period in the
reproductive function of female cattle. This review examines how the transforming growth …

Induction of immune-related gene expression by seminal exosomes in the porcine endometrium

R Bai, Z Latifi, K Kusama, K Nakamura… - Biochemical and …, 2018 - Elsevier
Seminal plasma (SP) is considered as a vehicle to carry sperm into female reproductive
tract, of which functions have not been completely understood. This study aimed to identify …

The effect of bta-miR-26b in intrauterine extracellular vesicles on maternal immune system during the implantation period

K Nakamura, K Kusama, M Hori, K Imakawa - Biochemical and Biophysical …, 2021 - Elsevier
Extracellular vesicles (EVs) in utero play a role in cellular interactions between endometrium-
conceptuses (embryo plus extraembryonic membranes) during peri-implantation periods …

IFNT-independent effects of intrauterine extracellular vesicles (EVs) in cattle

K Nakamura, K Kusama, A Ideta, K Imakawa… - …, 2020 - rep.bioscientifica.com
Extracellular vesicles (EVs) present in uterine lumen are involved in conceptus-endometrial
interactions during the pre-implantation period. Despite numerous studies conducted on …

[HTML][HTML] Analysis and screening of reproductive long non-coding RNAs through genome-wide analyses of goat endometrium during the pre-attachment phase

L Hong, Q Hu, X Zang, Y Xie, C Zhou, X Zou, Y Li… - Frontiers in …, 2020 - frontiersin.org
Reproduction in goat is highly impeded by implantation failure. Of concern, the underlying
mechanism leading to embryo implantation remains unclear. In this study, deep sequencing …

Regulation of human trophoblast cell syncytialization by transcription factors STAT5B and NR4A3

K Kusama, R Bai, K Imakawa - Journal of Cellular Biochemistry, 2018 - Wiley Online Library
In human trophoblast cells, cyclic AMP or its inducer forskolin (FSK) activates two
downstream signaling molecules, protein kinase A (PKA) and exchange protein directly …