BACKGROUND In a growth phase occurring during most of folliculogenesis, the oocyte
produces and accumulates molecules and organelles that are fundamental for the …

Meiotic progression in mammalian preovulatory follicles is controlled by the granulosa cells
around the oocyte. Cyclic GMP (cGMP) generated in the granulosa cells diffuses through …

Background Human reproduction depends on the fusion of a mature oocyte with a sperm
cell to form a fertilized egg. The genetic events that lead to the arrest of human oocyte …

Prior to ovulation, the mammalian oocyte undergoes a process of differentiation within the
ovarian follicle that confers on it the ability to give rise to an embryo. Differentiation …

Meiosis in mammalian oocytes is paused until luteinizing hormone (LH) activates receptors
in the mural granulosa cells of the ovarian follicle. Prior work has established the central role …

Thus far, the potential short-and long-term detrimental effects of a variety of environmental
chemicals designated as endocrine-active compounds (EACs) have been found to interfere …

Mammalian oocytes arrest at prophase of meiosis I at around birth and they remain arrested
at this stage until puberty when the preovulatory surge of luteinizing hormone (LH) causes …

Extensive damage to maternal DNA during meiosis causes infertility, birth defects and
abortions. However, it is unknown if fully grown oocytes have a mechanism to prevent the …

In mammals, the meiotic cell cycle of oocytes starts during embryogenesis and then pauses.
Much later, in preparation for fertilization, oocytes within preovulatory follicles resume …

In their midthirties, women experience a decline in fertility, coupled to a pronounced
increase in the risk of aneuploidy, miscarriage, and birth defects. Although the aetiology of …