The narrow therapeutic window of antiarrhythmic drugs (AADs) and their potential for lethal
proarrhythmia pose a unique clinical challenge without parallel in medical practice. 1 The …

Objectives. To review the historical development of amiodarone and the changing
perceptions of the drug, and discuss its electrophysiologic, pharmacologic, and …

To develop new approaches for the treatment of invasive infections caused by Aspergillus
fumigatus, the in vitro interactions between itraconazole (ITZ) and seven different …

Amiodarone is a first-line antiarrhythmic for life-threatening ventricular fibrillation or
ventricular tachycardia in children, yet little is known about its pharmacokinetics (PK) in this …

Background: Grapefruit juice causes significant QT prolongation in healthy volunteers and
naringenin has been identified as the most potent human ether-a-go-go-related gene …

Background—To date, the lack of potent and selective inhibitors has hampered the
physiological assessment of modulation of the cardiac slowly activating delayed rectifier …

Although implantable cardioverter-defibrillators (ICDs) can successfully terminate ventricular
arrhythmias, antiarrhythmic drugs are often required to prevent recurrent events. Class III …

Aims To compare the effects of sotalol and metoprolol on heart rate, during isotonic (ITE)
and isometric (IME) exercise and daily activities, in digitalized patients with chronic atrial …

The Next Generation of Antiarrhythmic Drugs. Five drugs currently constitute approximately
70% of the world market for antiarrhythmic medications. Since the publication of studies …

Cisapride and mosapride are structurally and pharmacologically related prokinetic agents.
In contrast to mosapride, cisapride causes embryonic lethality in teratology studies, and has …