[HTML][HTML] Phylogenetic and phylodynamic approaches to understanding and combating the early SARS-CoV-2 pandemic

SW Attwood, SC Hill, DM Aanensen… - Nature Reviews …, 2022 - nature.com
Determining the transmissibility, prevalence and patterns of movement of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is central to our understanding …

[HTML][HTML] SARS-CoV-2 one year on: evidence for ongoing viral adaptation

TP Peacock, R Penrice-Randal… - Journal of General …, 2021 - microbiologyresearch.org
SARS-CoV-2 is thought to have originated in the human population from a zoonotic spillover
event. Infection in humans results in a variety of outcomes ranging from asymptomatic cases …

[HTML][HTML] A novel cell culture system modeling the SARS-CoV-2 life cycle

X Ju, Y Zhu, Y Wang, J Li, J Zhang, M Gong… - PLoS …, 2021 - journals.plos.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the global
pandemic of COVID-19. SARS-CoV-2 is classified as a biosafety level-3 (BSL-3) agent …

[HTML][HTML] Infection of human Nasal Epithelial Cells with SARS-CoV-2 and a 382-nt deletion isolate lacking ORF8 reveals similar viral kinetics and host transcriptional …

AM Gamage, KS Tan, WOY Chan, J Liu, CW Tan… - PLoS …, 2020 - journals.plos.org
The novel coronavirus SARS-CoV-2 is the causative agent of Coronavirus Disease 2019
(COVID-19), a global healthcare and economic catastrophe. Understanding of the host …

Evaluation of NGS-based approaches for SARS-CoV-2 whole genome characterisation

C Charre, C Ginevra, M Sabatier, H Regue… - Virus …, 2020 - academic.oup.com
Since the beginning of the COVID-19 outbreak, SARS-CoV-2 whole-genome sequencing
(WGS) has been performed at unprecedented rate worldwide with the use of very diverse …

Role of CCL2/CCR2 axis in the pathogenesis of COVID-19 and possible Treatments: All options on the Table

M Ranjbar, A Rahimi, Z Baghernejadan… - International …, 2022 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is cause of the novel
coronavirus disease (COVID-19). In the last two years, SARS-CoV-2 has infected millions of …

ACE2-dependent and-independent SARS-CoV-2 entries dictate viral replication and inflammatory response during infection

T Duan, C Xing, J Chu, X Deng, Y Du, X Liu, Y Hu… - Nature Cell …, 2024 - nature.com
Excessive inflammation is the primary cause of mortality in patients with severe COVID-19,
yet the underlying mechanisms remain poorly understood. Our study reveals that ACE2 …

[HTML][HTML] Template switching and duplications in SARS-CoV-2 genomes give rise to insertion variants that merit monitoring

SK Garushyants, IB Rogozin, EV Koonin - Communications biology, 2021 - nature.com
The appearance of multiple new SARS-CoV-2 variants during the COVID-19 pandemic is a
matter of grave concern. Some of these variants, such as B. 1.617. 2, B. 1.1. 7, and B. 1.351 …

SARS-CoV-2 ORF8 accessory protein is a virulence factor

M Bello-Perez, J Hurtado-Tamayo, AZ Mykytyn… - Mbio, 2023 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes six accessory
proteins (3a, 6, 7a, 7b, 8, and 9b) for which limited information is available on their role in …

[HTML][HTML] SARS-CoV-2 does not have a strong effect on the nasopharyngeal microbial composition

T Braun, S Halevi, R Hadar, G Efroni, E Glick Saar… - Scientific Reports, 2021 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) has rapidly spread around the world,
impacting the lives of many individuals. Growing evidence suggests that the …