Simple Summary Nephrotoxicity is the dose-limiting factor of cisplatin treatment.
Nephrotoxicity is characterized by reduced kidney function. Although an often-reversible …

Cisplatin is a platinum-based chemotherapeutic that has long since been effective against a
variety of solid-cancers, substantially improving the five-year survival rates for cancer …

Sepsis is a systemic inflammatory disease that is caused by a dysregulated host response to
infection and is a life-threatening organ dysfunction that affects many organs, which includes …

Aims Cisplatin is a widely-used drug in the clinical treatment of tumors, but kidney
nephrotoxicity is one of the reasons that limits its widespread use. We previously found that …

Monotropein, a principal natural compound in iridoid glycosides extracted from Morindae
officinalis radix, has potent pharmacological activities. To understand and utilize …

Drug-induced nephrotoxicity (DIN) is a major cause of kidney damage and is associated
with high mortality and morbidity, which limits the clinical use of certain therapeutic or …

SIRT6 is an NAD+ dependent deacetylase that belongs to the mammalian sirtuin family.
SIRT6 is mainly located in the nucleus and regulates chromatin remodeling, genome …

Ethnopharmacological relevance Shenkang injection (SKI), a Chinese patent medicine
injection, has been approved for the treatment of chronic kidney disease (CKD) due to its …

The aim of this study was to investigate the molecular, biochemical, and histopathological
effects of bromelain, which has antioxidant and anti-inflammatory properties, against …

Monotropein (Mon) is a kind of iridoid glycoside plant secondary metabolite primarily
present in some edible and medicinal plants. The aim of this study was to investigate the …