PE_PGRS represent a large family of proteins typical of pathogenic mycobacteria whose
members are characterized by an N-terminal PE domain followed by a large Gly-Ala repeat …

The pathogenesis of periodontitis depends on a sustained feedback loop where bacterial
virulence factors and immune responses both contribute to inflammation and tissue …

The oral pathogen Porphyromonas gingivalis, as well as its purified fimbriae, are known to
activate TLR2 and induce proinflammatory and proadhesive effects. The TLR2 …

Despite representing a very important class of virulence proteins, the role of lipoproteins in
the pathogenesis of Mycobacterium tuberculosis remains elusive. In this study, we …

The lipid raft hypothesis proposed that these microdomains are small (10–200 nM), highly
dynamic and enriched in cholesterol, glycosphingolipids and signalling phospholipids …

TLR2 plays a role as a pattern-recognition receptor in the innate immune response involving
secreted proteins against microbial pathogens. To examine its possible involvement in the …

The complement and the Toll-like receptors are rapidly activatable systems which, in
concert, provide first-line innate defense against infection and act as mediators between the …

Abstract Interleukin‐34 (IL‐34) is a cytokine that supports the viability and differentiation of
macrophages. An important cytokine for the development of epidermal immunity, IL‐34, is …

The oral mucosal pathogen Porphyromonas gingivalis expresses at least two adhesins: the
67-kDa mfa-1 (minor) fimbriae and the 41-kDa fimA (major) fimbriae. In periodontal disease …

The impact of ageing in innate immunity is poorly understood. Studies in the mouse model
have described altered innate immune functions in aged macrophages, although these were …