Recent advances in hypertension and cardiovascular toxicities with vascular endothelial growth factor inhibition
This process is regulated by growth factors of which VEGFA–VEGFR2 plays a key role. 7
Inhibition of angiogenesis, by targeting VEGF–VEGFR signaling, has revolutionized cancer …
Inhibition of angiogenesis, by targeting VEGF–VEGFR signaling, has revolutionized cancer …
[HTML][HTML] Natural products from polar organisms: structural diversity, bioactivities and potential pharmaceutical applications
Natural products have a huge value in pharmaceuticals industry as molecules or templates
for discovery or further development of new drugs. It is predicted that, if the marine resources …
for discovery or further development of new drugs. It is predicted that, if the marine resources …
Carbohydrate-based peptidomimetics targeting neuropilin-1: Synthesis, molecular docking study and in vitro biological activities
M Richard, A Chateau, C Jelsch, C Didierjean… - Bioorganic & Medicinal …, 2016 - Elsevier
Abstract Neuropilin-1 (NRP-1), a transmembrane glycoprotein acting as a co-receptor of
VEGF-A, is expressed by cancer and angiogenic endothelial cells and is involved in the …
VEGF-A, is expressed by cancer and angiogenic endothelial cells and is involved in the …
[HTML][HTML] SH003 represses tumor angiogenesis by blocking VEGF binding to VEGFR2
HS Choi, MK Kim, K Lee, KM Lee, YK Choi, YC Shin… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Tumor angiogenesis is a key feature of cancer progression, because a tumor requires
abundant oxygen and nutrition to grow. Here, we demonstrate that SH003, a mixed herbal …
abundant oxygen and nutrition to grow. Here, we demonstrate that SH003, a mixed herbal …
Looking for the word “angiogenesis” in the history of health sciences: from ancient times to the first decades of the twentieth century
G Natale, G Bocci, P Lenzi - World journal of surgery, 2017 - Springer
This review deals with the origin of the term “angiogenesis”, with an attention to John Hunter
who is credited with this neologism. A part of the literature refers to a Hunter's work dating …
who is credited with this neologism. A part of the literature refers to a Hunter's work dating …
Anti-angiogenic activity of azathioprine
AV de Melo Bisneto, AS Fernandes, VSV Sá… - Microvascular …, 2021 - Elsevier
Azathioprine (AZA) is the main drug used in immunomodulatory therapy in post-transplant
patients or with autoimmune diseases. However, no study has evaluated the AZA …
patients or with autoimmune diseases. However, no study has evaluated the AZA …
Bidirectional regulation of angiogenesis by phytoestrogens through estrogen receptor-mediated signaling networks
LIU Hai-Xin, W Yu, LU Qing, Y Ming-Zhu… - Chinese journal of …, 2016 - Elsevier
Sex hormone estrogen is one of the most active intrinsic angiogenesis regulators; its
therapeutic use has been limited due to its carcinogenic potential. Plant-derived …
therapeutic use has been limited due to its carcinogenic potential. Plant-derived …
[HTML][HTML] Human endoglin-CD3 bispecific T cell engager antibody induces anti-tumor effect in vivo
L Zhong, W Shi, L Gan, X Liu, Y Huo, P Wu, Z Zhang… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Endoglin, also known as CD105, is a homo-dimeric membrane glycoprotein
required for angiogenesis and serves as a marker for cancer vasculature. In this study, we …
required for angiogenesis and serves as a marker for cancer vasculature. In this study, we …
Synthesis of honokiol analogues and evaluation of their modulating action on VEGF protein secretion and telomerase‐related gene expressions
M Sánchez‐Peris, J Murga, E Falomir… - Chemical Biology & …, 2017 - Wiley Online Library
A group of 36 biphenyl derivatives structurally related to honokiol were synthesized by
means of Suzuki coupling reactions. Their cytotoxicities were evaluated and compared to …
means of Suzuki coupling reactions. Their cytotoxicities were evaluated and compared to …
[HTML][HTML] Analytic and Dynamic Secretory Profile of Patient-Derived Cytokine-lnduced Killer Cells
G Mesiano, R Zini, G Montagner, N Bianchi… - Molecular …, 2017 - Springer
Adoptive immunotherapy with cytokine induced killer (CIK) cells has shown antitumor activity
against several kinds of cancer in preclinical models and clinical trials. CIK cells are a …
against several kinds of cancer in preclinical models and clinical trials. CIK cells are a …