Functions of bromodomain-containing proteins and their roles in homeostasis and cancer
T Fujisawa, P Filippakopoulos - Nature reviews Molecular cell biology, 2017 - nature.com
Bromodomains (BRDs) are evolutionarily conserved protein–protein interaction modules
that are found in a wide range of proteins with diverse catalytic and scaffolding functions and …
that are found in a wide range of proteins with diverse catalytic and scaffolding functions and …
Understanding histone H3 lysine 36 methylation and its deregulation in disease
Methylation of histone H3 lysine 36 (H3K36) plays crucial roles in the partitioning of
chromatin to distinctive domains and the regulation of a wide range of biological processes …
chromatin to distinctive domains and the regulation of a wide range of biological processes …
Functional roles of bromodomain proteins in cancer
Simple Summary This review provides an in depth analysis of the role of bromodomain-
containing proteins in cancer development. As readers of acetylated lysine on nucleosomal …
containing proteins in cancer development. As readers of acetylated lysine on nucleosomal …
ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
Abstract Recurring chromosomal translocation t (10; 17)(p15; q21) present in a subset of
human acute myeloid leukemia (AML) patients creates an aberrant fusion gene termed …
human acute myeloid leukemia (AML) patients creates an aberrant fusion gene termed …
Autophagy mediates glucose starvation-induced glioblastoma cell quiescence and chemoresistance through coordinating cell metabolism, cell cycle, and survival
Metabolic reprogramming is pivotal to sustain cancer growth and progression. As such
dietary restriction therapy represents a promising approach to starve and treat cancers …
dietary restriction therapy represents a promising approach to starve and treat cancers …
Clinicopathological and molecular analysis of multinodular and vacuolating neuronal tumors of the cerebrum
E Choi, SI Kim, JK Won, CK Chung, SK Kim, SH Choi… - Human Pathology, 2019 - Elsevier
Multinodular and vacuolating neuronal tumor (MVNT) of the cerebrum is a recently
recognized rare neuronal tumor, and its pathogenesis is unclear. We analyzed 7 cases of …
recognized rare neuronal tumor, and its pathogenesis is unclear. We analyzed 7 cases of …
Computational gene expression analysis reveals distinct molecular subgroups of T-cell prolymphocytic leukemia
T-cell prolymphocytic leukemia (T-PLL) is a rare blood cancer with poor prognosis.
Overexpression of the proto-oncogene TCL1A and missense mutations of the tumor …
Overexpression of the proto-oncogene TCL1A and missense mutations of the tumor …
Increased association between Epstein-Barr virus EBNA2 from type 2 strains and the transcriptional repressor BS69 restricts EBNA2 activity
R Ponnusamy, R Khatri, PB Correia, CD Wood… - PLoS …, 2019 - journals.plos.org
Natural variation separates Epstein-Barr virus (EBV) into type 1 and type 2 strains. Type 2
EBV is less transforming in vitro due to sequence differences in the EBV transcription factor …
EBV is less transforming in vitro due to sequence differences in the EBV transcription factor …
[HTML][HTML] Structural basis for EPC1-mediated recruitment of MBTD1 into the NuA4/TIP60 acetyltransferase complex
Summary MBTD1, a H4K20me reader, has recently been identified as a component of the
NuA4/TIP60 acetyltransferase complex, regulating gene expression and DNA repair …
NuA4/TIP60 acetyltransferase complex, regulating gene expression and DNA repair …
Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes
A recurrent chromosomal translocation found in acute myeloid leukemia leads to an in-frame
fusion of the transcription repressor ZMYND11 to MBTD1, a subunit of the NuA4/TIP60 …
fusion of the transcription repressor ZMYND11 to MBTD1, a subunit of the NuA4/TIP60 …