DNA G-quadruplex in human telomeres and oncogene promoters: structures, functions, and small molecule targeting
Conspectus DNA G-quadruplex secondary structures formed in guanine-rich human
telomeres and oncogene promoters are functionally important and have emerged as a …
telomeres and oncogene promoters are functionally important and have emerged as a …
[HTML][HTML] On the road to fight cancer: The potential of G-quadruplex ligands as novel therapeutic agents
I Alessandrini, M Recagni, N Zaffaroni… - International journal of …, 2021 - mdpi.com
Nucleic acid sequences able to adopt a G-quadruplex conformation are overrepresented
within the human genome. This evidence strongly suggests that these genomic regions …
within the human genome. This evidence strongly suggests that these genomic regions …
Supramolecular Self‐Assembly‐Facilitated Aggregation of Tumor‐Specific Transmembrane Receptors for Signaling Activation and Converting Immunologically Cold …
J Li, Y Fang, Y Zhang, H Wang, Z Yang… - Advanced …, 2021 - Wiley Online Library
Supramolecular self‐assembling peptide systems are attracting increasing interest in the
field of cancer theranostics. Additionally, transformation of the immunologically cold tumor …
field of cancer theranostics. Additionally, transformation of the immunologically cold tumor …
Structural recognition of the MYC promoter G-quadruplex by a quinoline derivative: insights into molecular targeting of parallel G-quadruplexes
J Dickerhoff, J Dai, D Yang - Nucleic Acids Research, 2021 - academic.oup.com
Abstract DNA G-Quadruplexes (G4s) formed in oncogene promoters regulate transcription.
The oncogene MYC promoter G4 (MycG4) is the most prevalent G4 in human cancers …
The oncogene MYC promoter G4 (MycG4) is the most prevalent G4 in human cancers …
Rational design of small-molecules to recognize G-quadruplexes of c-MYC promoter and telomere and the evaluation of their in vivo antitumor activity against breast …
W Long, BX Zheng, Y Li, XH Huang, DM Lin… - Nucleic acids …, 2022 - academic.oup.com
DNA G4-structures from human c-MYC promoter and telomere are considered as important
drug targets; however, the developing of small-molecule-based fluorescent binding ligands …
drug targets; however, the developing of small-molecule-based fluorescent binding ligands …
[HTML][HTML] Structural insight into the bulge-containing KRAS oncogene promoter G-quadruplex bound to berberine and coptisine
KB Wang, Y Liu, J Li, C Xiao, Y Wang, W Gu… - Nature …, 2022 - nature.com
KRAS is one of the most highly mutated oncoproteins, which is overexpressed in various
human cancers and implicated in poor survival. The G-quadruplex formed in KRAS …
human cancers and implicated in poor survival. The G-quadruplex formed in KRAS …
Structure of the Major G-Quadruplex in the Human EGFR Oncogene Promoter Adopts a Unique Folding Topology with a Distinctive Snap-Back Loop
Y Liu, J Li, Y Zhang, Y Wang, J Chen… - Journal of the …, 2023 - ACS Publications
EGFR tyrosine kinase inhibitors have made remarkable success in targeted cancer therapy.
However, therapeutic resistance inevitably occurred and EGFR-targeting therapy has been …
However, therapeutic resistance inevitably occurred and EGFR-targeting therapy has been …
Rhodium-Catalyzed [4+ 2] Cascade Annulation to Easy Access N-Substituted Indenoisoquinolinones
X Yue, Y Gao, J Huang, Y Feng, X Cui - Organic Letters, 2023 - ACS Publications
An efficient approach for the synthesis of N-substituted indenoisoquinolinones via rhodium
(III)-catalyzed C–H bond activation/subsequent [4+ 2] cyclization starting from easily …
(III)-catalyzed C–H bond activation/subsequent [4+ 2] cyclization starting from easily …
[HTML][HTML] Overview of nanoparticle-based approaches for the combination of Photodynamic Therapy (PDT) and chemotherapy at the preclinical stage
Simple Summary The present review represents the outstanding and promising recent
literature reports (2017–2022) on nanoparticle-based formulations developed for anticancer …
literature reports (2017–2022) on nanoparticle-based formulations developed for anticancer …
[HTML][HTML] Structured waters mediate small molecule binding to G-quadruplex nucleic acids
S Neidle - Pharmaceuticals, 2021 - mdpi.com
The role of G-quadruplexes in human cancers is increasingly well-defined. Accordingly, G-
quadruplexes can be suitable drug targets and many small molecules have been identified …
quadruplexes can be suitable drug targets and many small molecules have been identified …