Emergence, transmission dynamics and mechanisms of artemisinin partial resistance in malaria parasites in Africa
PJ Rosenthal, V Asua, MD Conrad - Nature Reviews Microbiology, 2024 - nature.com
Malaria, mostly due to Plasmodium falciparum infection in Africa, remains one of the most
important infectious diseases in the world. Standard treatment for uncomplicated P …
important infectious diseases in the world. Standard treatment for uncomplicated P …
[HTML][HTML] Artemisinin and multidrug-resistant Plasmodium falciparum–a threat for malaria control and elimination
M Dhorda, C Amaratunga… - Current opinion in …, 2021 - journals.lww.com
Enhancing the geographic coverage of surveillance for resistance will be key to ensure
prompt detection of emerging resistance in order to implement effective countermeasures …
prompt detection of emerging resistance in order to implement effective countermeasures …
Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness
The emergence of mutant K13-mediated artemisinin (ART) resistance in Plasmodium
falciparum malaria parasites has led to widespread treatment failures across Southeast …
falciparum malaria parasites has led to widespread treatment failures across Southeast …
Artemisinin-resistant K13 mutations rewire Plasmodium falciparum's intra-erythrocytic metabolic program to enhance survival
The emergence and spread of artemisinin resistance, driven by mutations in Plasmodium
falciparum K13, has compromised antimalarial efficacy and threatens the global malaria …
falciparum K13, has compromised antimalarial efficacy and threatens the global malaria …
[HTML][HTML] Plasmodium falciparum resistance to ACTs: Emergence, mechanisms, and outlook
Emergence and spread of resistance in Plasmodium falciparum to the frontline treatment
artemisinin-based combination therapies (ACTs) in the epicenter of multidrug resistance of …
artemisinin-based combination therapies (ACTs) in the epicenter of multidrug resistance of …
Emergence of artemisinin-based combination treatment failure in patients returning from sub-Saharan Africa with P. falciparum malaria
T Grossman, J Vainer, Y Paran… - Journal of Travel …, 2023 - academic.oup.com
Background Artemisinin-based combination therapies (ACTs) are recommended as first-line
treatment against uncomplicated Plasmodium falciparum infection. Mutations in the …
treatment against uncomplicated Plasmodium falciparum infection. Mutations in the …
Malaria molecular surveillance in the Peruvian Amazon with a novel highly multiplexed Plasmodium falciparum AmpliSeq assay
JH Kattenberg, C Fernandez-Miñope… - Microbiology …, 2023 - Am Soc Microbiol
Molecular surveillance for malaria has great potential to support national malaria control
programs (NMCPs). To bridge the gap between research and implementation, several …
programs (NMCPs). To bridge the gap between research and implementation, several …
Bangladesh in the era of malaria elimination
Bangladesh has dramatically reduced malaria by 93% from 2008 to 2020. The strategy has
been district-wise, phased elimination; however, the last districts targeted for elimination …
been district-wise, phased elimination; however, the last districts targeted for elimination …
The newly discovered role of endocytosis in artemisinin resistance
HM Behrens, S Schmidt… - Medicinal Research …, 2021 - Wiley Online Library
Artemisinin and its derivatives (ART) are the cornerstone of malaria treatment as part of
artemisinin combination therapy (ACT). However, reduced susceptibility to artemisinin as …
artemisinin combination therapy (ACT). However, reduced susceptibility to artemisinin as …
[HTML][HTML] Multidisciplinary investigations of sustained malaria transmission in the Greater Mekong Subregion
In the course of malaria elimination in the Greater Mekong Subregion (GMS), malaria
epidemiology has experienced drastic spatiotemporal changes with residual transmission …
epidemiology has experienced drastic spatiotemporal changes with residual transmission …