Ninety percent of clinical drug development fails despite implementation of many successful
strategies, which raised the question whether certain aspects in target validation and drug …

Radiotherapy (RT) is a cornerstone treatment strategy for brain tumours. Besides
cytotoxicity, RT can cause disruption of the blood–brain barrier (BBB), resulting in an …

Carbamoyl fluoride is a fluorinated group that, to this date, remains underexplored, probably
due to the lack of data concerning its properties. In this paper, a study of carbamoyl fluoride …

In this review the applications of isotopically labeled compounds are discussed and put into
the context of their future impact in the life sciences. Especially discussing their use in the …

Positron emission tomography (PET) imaging is used in drug development to noninvasively
measure biodistribution and receptor occupancy. Ideally, PET tracers retain target binding …

Positron emission tomography (PET) is a powerful tool for imaging biological processes in
the central nervous system (CNS). Designing PET radiotracers capable of crossing the …

Efficient methods for labeling aryl trifluoromethyl groups to provide novel radiotracers for use
in biomedical research with positron emission tomography (PET) are keenly sought. We …

Ground‐breaking research in disease biology and continuous efforts in method
development have uncovered a range of potential new drug targets. Increasingly, the drug …

Drug optimization, which improves drug potency/specificity by structure‒activity relationship
(SAR) and drug-like properties, is rigorously performed to select drug candidates for clinical …

Stress-activated kinases are targets of interest in neurodegenerative disease due to their
involvement in inflammatory signaling and synaptic dysfunction. The p38α kinase has …