Cholesterol metabolism produces essential membrane components as well as metabolites
with a variety of biological functions. In the tumour microenvironment, cell-intrinsic and cell …

Abstract γδ T cells play uniquely important roles in stress surveillance and immunity for
infections and carcinogenesis. Human γδ T cells recognize and kill transformed cells …

Bone metastases are a frequent and severe complication of advanced-stage cancers. Breast
and prostate cancers, the most common malignancies in women and men, respectively …

T lymphocytes (T cells) are divided into two functionally different subgroups the CD4+ T
helper cells (Th) and the CD8+ cytotoxic T lymphocytes (CTL). Adequate CD4 and CD8 T …

CD8+ T cells are master effectors of antitumor immunity, and their presence at tumor sites
correlates with favorable outcomes. However, metabolic constraints imposed by the tumor …

Cancer is a multifaceted global disease. Transformation of a normal to a malignant cell takes
several steps, including somatic mutations, epigenetic alterations, metabolic reprogramming …

Innate immune cells can develop exacerbated immunologic response and long-term
inflammatory phenotype following brief exposure to endogenous or exogenous insults …

Simple Summary Metabolic reprogramming is gaining attentions as a hallmark of cancers.
However, lipid metabolism has been difficult to analyze due to technical problems. In recent …

Cancer stem cells (CSCs) are a sub-population of tumour cells, which are responsible to
drive tumour growth, metastasis and therapy resistance. It has recently been proposed that …

Apart from their activity in combating infections, neutrophils play an important role in
regulating the tumor microenvironment. Neutrophils can directly kill (antibody-coated) …